17-Hydroxyprogesterone

17-hydroxyprogesterone (17-OHP) is an intermediate hormone produced during cortisol synthesis. This test, typically performed on newborn screening bloodspots, measures 17-OHP levels to detect congenital adrenal hyperplasia (CAH), a genetic disorder affecting hormone production. Elevated levels indicate impaired cortisol synthesis, which can cause serious metabolic and electrolyte imbalances. Early detection through newborn screening allows prompt treatment to prevent life-threatening complications and developmental problems.