3-Hydroxyvalerate

ChemistryAlso known as: 3oh-valeric acidAlso known as: 3-Hydroxyvaleric acidN/A

Detects an organic acid in urine indicating fat and amino acid metabolism status.

Normal Range

Consult your provider

N/A

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Elevated 3-hydroxyvalerate suggests serious metabolic disorders. Early detection through screening enables immediate dietary and medical interventions to prevent severe complications.

Overview

3-Hydroxyvalerate is an organic acid produced during fat and amino acid metabolism. Elevated urine levels can signal metabolic disorders such as propionic acidemia, methylmalonic acidemia, or other organic acid disorders. These rare inherited conditions affect how the body processes certain nutrients and can cause seizures, developmental delays, and organ damage. This test is commonly used in newborn screening programs and for evaluating unexplained metabolic symptoms in children and adults.

Research & Evidence

13 publications

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Enhanced denitrification performance of constructed wetlands for wastewater treatment plant effluent using zero-valent iron-based mixing solid carbon sources.

Bioresour Technol · 2026

PMID: 41605279Other

Microbial conversion of waste-derived short-chain fatty acids into poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV): A review.

Int J Biol Macromol · 2026

PMID: 41850451

Biorefining of kitchen waste for the targeted production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) through open mixed microbial fermentation model.

Int J Biol Macromol · 2026

PMID: 41999821

Anaerobic Fermentation of Poly(3-hydroxybutyrate--3-hydroxyvalerate) Plasticized with Glycerol Trilevulinate into Volatile Fatty Acids.

ACS Omega · 2026

PMID: 42004329

Physicochemical and Osteoinductive Comparison of 2D Spin-Coated Films and 3D Porous Solvent-Cast Scaffolds of Poly(3-Hydroxybutyrate--3-Hydroxyvalerate) (PHBV)/ Polybutylene Adipate Terephthalate (PBAT) Blends.

ACS Biomater Sci Eng · 2026

PMID: 41962034

Study of the Biosynthesis of Poly(3-hydroxybutyrate--3-hydroxyvalerate) with High Content in 3-Hydroxyvalerate Units byH1 G3 (DSM 545).

Biomacromolecules · 2026

PMID: 41784508

Polymer-specific effects of biodegradable plastic-derived microplastics on anaerobic digestion performance and microbial pathways.

Bioresour Technol · 2026

PMID: 41997247

Molecular Insights into Miscibility and Mechanical Modulation in PHBV/Chitosan Blends via Atomistic Simulations.

Polymer (Guildf) · 2026

PMID: 42005045

Energy-efficient selection of high-yield PHA producers via microaerophilic uncoupled feeding.

Bioresour Technol · 2026

PMID: 42019691

Bio-upcycling of bioplastic wastes into polyhydroxyalkanoates.

Bioresour Technol · 2026

PMID: 41620045

Research data from MEDLINE/PubMed · 13 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

29627-7Primary

3-Hydroxyvalerate [Presence] in Urine

47820-6

3-Hydroxyvalerate [Moles/volume] in Plasma

umol/L

50098-3

3-Hydroxyvalerate [Moles/volume] in Cerebral spinal fluid

umol/L

Available Lab Tests

Order tests that measure this biomarker

Urinary Organic Acids

Results in 7-14 business days

3-Hydroxyvalerate: Normal Range, Testing & Clinical Significance | Healos | Healos