3-Methylcrotonylglycine

3-Methylcrotonylglycine is a metabolite detected in urine that indicates abnormal metabolism of the amino acid leucine. Elevated levels suggest possible 3-methylcrotonyl-CoA carboxylase deficiency, a genetic metabolic disorder affecting how your body processes branched-chain amino acids. This condition can cause developmental delay, low muscle tone, and metabolic acidosis if untreated. Early detection through newborn screening allows for dietary management. This test is part of comprehensive metabolic screening, especially in newborns.