4-Hydroxyphenylpyruvate

ChemistryAlso known as: 4oh-phenylpyruvic acidAlso known as: 4-Hydroxyphenylpyruvic acidN/A

Detects 4-hydroxyphenylpyruvate in serum or plasma, indicating tyrosine metabolism disorders.

Normal Range

Consult your provider

N/A

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Elevated levels indicate tyrosinemia, a serious genetic disorder. Early detection through newborn screening enables dietary management and treatment to prevent liver cirrhosis and kidney failure.

Overview

4-Hydroxyphenylpyruvate (4-HPP) is a compound found in urine that appears elevated in tyrosinemia, a genetic disorder affecting amino acid metabolism. Tyrosinemia impairs the breakdown of the amino acid tyrosine, leading to toxic buildup affecting the liver, kidneys, and eyes. Early detection through urine screening, particularly in newborns, is critical for starting dietary restriction and medical treatment. Untreated tyrosinemia causes liver cirrhosis, kidney failure, and increased cancer risk.

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

72428-6Primary

4-Hydroxyphenylpyruvate [Moles/volume] in Serum or Plasma

umol/L

29871-1

4-Hydroxyphenylpyruvate [Presence] in Urine

72427-8

4-Hydroxyphenylpyruvate [Moles/volume] in Cerebral spinal fluid

umol/L

Available Lab Tests

Order tests that measure this biomarker

Urinary Organic Acids

$586.08

Results in 7-14 business days