5-Oxoproline

ChemistryAlso known as: 5-oxo-prolineAlso known as: pyroglutamic acidAlso known as: pyroglutamateN/A

Detects the presence of 5-oxoproline in serum or plasma, an amino acid metabolite.

Normal Range

Consult your provider

N/A

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Elevated 5-oxoproline suggests glutathione metabolism disorders or medication-related metabolic disruption. Identifying the cause is important to prevent accumulation and manage any underlying enzyme deficiency.

Overview

5-oxoproline (pyroglutamic acid) is an organic acid that accumulates in urine when your body's glutathione metabolism is disrupted. Elevated urinary 5-oxoproline may indicate 5-oxoprolinase deficiency, a rare inherited metabolic disorder affecting amino acid processing. It can also be elevated with certain medications (particularly acetaminophen overuse), illness, or nutritional deficiencies. This finding warrants evaluation by a metabolic specialist to determine the underlying cause and appropriate management.

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

75089-3Primary

5-Oxoproline [Moles/volume] in Serum or Plasma

umol/L

29872-9

5-Oxoproline [Presence] in Urine

43633-7

5-Oxoproline [Presence] in 24 hour Urine

Available Lab Tests

Order tests that measure this biomarker

Urinary Organic Acids

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