Glutarate

Glutarate is an organic acid that accumulates in urine when lysine and tryptophan metabolism is disrupted. Elevated urinary glutarate indicates glutaric aciduria, a rare inherited metabolic disorder. This condition can cause progressive neurological damage, developmental delays, movement disorders, and brain degeneration if left untreated. Early detection through newborn screening is critical, but this test may identify missed cases in older individuals. Positive results require prompt evaluation and specialized metabolic management.