Histidine

ChemistryAlso known as: L-HistidineAlso known as: 2-amino-3-(1H-imidazol-4-yl)propanoic acidnmol/mL

Measures the amount of histidine excreted in serum or plasma.

Normal Range

0.2 – 1 nmol/mL

nmol/mL

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Abnormal histidine levels may indicate nutritional deficiency, malabsorption, kidney disease, or metabolic disorders affecting amino acid metabolism.

Understanding Your Results

Normal Range

0.2 – 1 nmol/mL

Overview

Histidine is an essential amino acid required for protein synthesis, immune function, and tissue repair. A urine histidine test measures how much histidine your body is excreting, reflecting nutritional intake, protein metabolism, and kidney function. Elevated urinary histidine may indicate excessive protein intake, kidney disease, or rare metabolic disorders. Low levels may suggest nutritional deficiency or malabsorption. This test helps assess amino acid metabolism and nutritional status.

Research & Evidence

100 publications

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Scalable production and characterization of recombinant pneumococcal histidine triad protein D in Escherichia coli for vaccine development.

Protein Expr Purif · 2026

PMID: 41539420Other

Histidines promote zinc over cadmium binding to the single type 4 metallothionein from Great Millet (Sorghum bicolor).

J Inorg Biochem · 2026

PMID: 41570457Other

Immunoblot-based activity assay for heme-containing histidine kinases.

J Biol Inorg Chem · 2026

PMID: 42053783

Antifungal repurposing of clinical chelator DMSA against Cryptococcus neoformans via laccase and histidine biosynthesis inhibition.

Microb Pathog · 2026

PMID: 41679612

Targeting bacitracin resistance-associated histidine kinase (BraS) in MRSA with isatin and indazole derivatives.

Sci Rep · 2026

PMID: 42056199

Covalent Targeting of Histidine Residues: A Ligand-First Approach.

J Med Chem · 2026

PMID: 42054250

Substrate selectivity of human histidine methyltransferase METTL9.

Protein Sci · 2026

PMID: 42050879

Integrating bulk and single-cell transcriptomic data to construct a risk model for histidine metabolism-related epithelial cell features in lung adenocarcinoma, predicting prognosis and immune landscape.

RNA Biol · 2026

PMID: 42003422

Revisiting enzyme engineering strategies and reaction mechanisms of lytic polysaccharide monooxygenases (LPMOs).

Crit Rev Biotechnol · 2026

PMID: 41629066

Histidine-Derived N, O-Codoped Porous Carbon Materials as Supercapacitor Electrodes.

Langmuir · 2026

PMID: 42053573

Research data from MEDLINE/PubMed · 100 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

27972-9Primary

Histidine [Units/volume] in Serum or Plasma

[arb'U]/mL

27904-2

Histidine [Moles/volume] in Urine

nmol/mL

2421-6

Histidine [Presence] in Serum or Plasma

2418-2

Histidine [Presence] in Blood

25926-7

Histidine [Moles/volume] in 24 hour Urine

umol/L

2420-8

Histidine [Mass/volume] in Serum or Plasma

mg/dL

25440-9

Histidine [Moles/time] in 24 hour Urine

umol/(24.h)

22717-3

Histidine [Moles/volume] in Specimen

umol/L

9453-2

Histidine [Moles/volume] in Cerebral spinal fluid

umol/L

20645-8

Histidine [Moles/volume] in Serum or Plasma

umol/L

2423-2

Histidine [Mass/volume] in Urine

mg/dL

2422-4

Histidine [Presence] in Urine

26808-6

Histidine [Presence] in 24 hour Urine

27111-4

Histidine [Moles/volume] in Amniotic fluid

umol/dL

2419-0

Histidine [Mass/volume] in Blood

mg/dL

32246-1

Histidine [Moles/volume] in Body fluid

umol/L

32247-9

Histidine [Moles/volume] in Vitreous fluid

umol/L

47643-2

Histidine [Moles/volume] in DBS

umol/L

55874-2

Histidine [Moles/mass] in Hair

umol/g

2424-0

Histidine [Mass/time] in 24 hour Urine

mg/(24.h)

13398-3

Histidine [Mass/volume] in Amniotic fluid

mg/dL

Available Lab Tests

Order tests that measure this biomarker

Amino Acids (Plasma)

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