Nicotine

ToxicologyAlso known as: Nicotine DoseAlso known as: Nicotine Gast QlAlso known as: Nicotine Gast-sCncN/A

Qualitatively detects the presence of nicotine or its metabolites in a specimen.

Normal Range

Consult your provider

N/A

Abnormal Levels

Consult your provider

Specimen Type

Blood

Why This Biomarker Matters

Confirms recent nicotine exposure and may impact insurance rates, employment eligibility, or help monitor adherence to smoking cessation efforts.

Overview

This qualitative test detects the presence or absence of nicotine in a biological specimen, commonly used in urine or saliva screening. The test identifies nicotine metabolites to verify tobacco or nicotine product use. It is employed for employment screening, insurance underwriting, monitoring compliance with smoking cessation programs, or clinical assessment of nicotine exposure. A positive result indicates recent nicotine exposure from cigarettes, vaping, patches, or other nicotine-containing products.

Research & Evidence

100 publications

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Nitrosamine and nicotine exposure after switching from filtered to unfiltered cigarette smoking: a cross-over clinical trial.

Tob Control · 2024

PMID: 39433390Other

Nicotine metabolite ratio and clinically significant depressive symptoms in U.S. adults: A smoker-specific association.

Medicine (Baltimore) · 2026

PMID: 41961715

To Vape or Not to Vape: Oral Health in the Age of Electronic Nicotine Delivery Systems and Electronic Non-Nicotine Delivery Systems.

Int Dent J · 2026

PMID: 41932095

Flavourings, nicotine content, and elemental composition as indicators of regulatory compliance in nicotine pouches and heated tobacco products.

Analyst · 2026

PMID: 41973076

A systematic review and meta-analysis of the association between e-cigarette use and cigarette abstinence or changes in continued cigarette smoking among individuals who smoke cigarettes.

Harm Reduct J · 2026

PMID: 41981605

Comment on "Nicotine drives acute epithelial injury in region-specific human airway models at the air-liquid interface after e-cigarette aerosol exposure".

Toxicology · 2026

PMID: 41887452

Nicotinic acetylcholine receptors-targeting drug discovery.

Eur J Med Chem · 2026

PMID: 41734592

Nicotine-Inspired, De Novo-Designed SARS-CoV-2 Main Protease Inhibitors Reveal Unique Chemistry for Covalently Conjugating Both Cysteine and Histidine Residues in the Catalytic Dyad.

J Am Chem Soc · 2026

PMID: 41978983

U.S. healthcare provider risk perceptions of tobacco and nicotine-containing products.

Intern Emerg Med · 2026

PMID: 41973176

Canal Cholesteatoma Presentation and Management: A Systematic Review and Meta-Analysis.

Otolaryngol Head Neck Surg · 2026

PMID: 41979387

Research data from MEDLINE/PubMed · 100 articles

Technical Information (LOINC Codes)

Standardized laboratory codes for this biomarker

55557-3Primary

Nicotine [Moles/volume] in Serum or Plasma

nmol/L

3854-7

Nicotine [Mass/volume] in Urine

ng/mL

43830-9

Nicotine [Presence] in Specimen

43195-7

Nicotine [Presence] in Urine by Confirmatory method

55558-1

Nicotine [Moles/volume] in Serum or Plasma by Screen method

umol/L

12294-5

Nicotine [Presence] in Urine

3853-9

Nicotine [Mass/volume] in Serum or Plasma

ng/mL

4350-5

Nicotine [Mass] of Dose

40386-5

Nicotine [Presence] in Hair

40385-7

Nicotine [Presence] in Meconium

59936-5

Nicotine [Moles/volume] in Urine

nmol/L

59937-3

Nicotine [Moles/volume] in Gastric fluid

nmol/L

60320-9

Nicotine [Moles/volume] in Specimen

nmol/L

80541-6

Nicotine [Mass/mass] in Hair

pg/mg

40387-3

Nicotine [Presence] in Gastric fluid

87596-3

Nicotine [Mass/mass] in Specimen

mg/kg; [ppm]

Available Lab Tests

Order tests that measure this biomarker

nicotine and expanded metabolites urine test

$56.85