Orotate

Orotate is an organic compound involved in the synthesis of nucleotides, the building blocks of DNA and RNA. This urine test detects abnormal orotate levels, which may indicate a rare inherited metabolic disorder called orotic aciduria. In this condition, the body cannot properly process orotate, leading to its accumulation and excretion in urine. This can cause developmental delays, anemia, and growth problems. Early diagnosis through urine screening is essential for initiating specialized treatment with uridine supplementation, which can prevent serious developmental and health complications.