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Autoimmune lymphoproliferative syndrome

disorder
SNOMED 702444009CUI C1328840

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Autoimmunity
Very frequent (80-99%)HP:0002960
Chronic noninfectious lymphadenopathy
Very frequent (80-99%)HP:0002730
Large spleen
Very frequent (80-99%)HP:0001744
Lymph node hyperplasia
Very frequent (80-99%)HP:0002716
Abnormal T cell apoptosis
Frequent (30-79%)HP:0030886
Abnormality of interleukin secretion
Frequent (30-79%)HP:0011117
Autoimmune haemolytic anemia
Frequent (30-79%)HP:0001890
Bleeding tendency
Frequent (30-79%)HP:0001892
Bruising susceptibility
Frequent (30-79%)HP:0000978
Enlarged liver
Frequent (30-79%)HP:0002240
Hyperglobulinemia
Frequent (30-79%)HP:0010702
Hypersplenism
Frequent (30-79%)HP:0001971
Immune thrombocytopenia
Frequent (30-79%)HP:0001973
Increased circulating interleukin 10 concentration
Frequent (30-79%)HP:0033199
Increased number of B cells
Frequent (30-79%)HP:0005404
Increased number of CD4-/CD8- T cells expressing alpha/beta T-cell receptors
Frequent (30-79%)HP:0002851
Increased total IgG in blood
Frequent (30-79%)HP:0003237
Neutropenia in presence of anti-neutropil antibodies
Frequent (30-79%)HP:0001904
Abnormal CD4+ T cell subset proportion
Occasional (5-29%)HP:0031392
Abnormal CD8+ T cell proportion
Occasional (5-29%)HP:0031393
Abnormal vitamin B12 level
Occasional (5-29%)HP:0040126
Absolute lymphocyte count decrease
Occasional (5-29%)HP:0001888
Antineutrophil antibody positivity
Occasional (5-29%)HP:0003453
Antinuclear antibodies
Occasional (5-29%)HP:0003493
Antiphospholipid antibodies
Occasional (5-29%)HP:0003613
B-cell lymphoma
Occasional (5-29%)HP:0012191
Burkitt lymphoma
Occasional (5-29%)HP:0030080
Decreased circulating total IgM
Occasional (5-29%)HP:0002850
Decreased proportion of CD4-positive T cells
Occasional (5-29%)HP:0032218
Decreased serum IgG
Occasional (5-29%)HP:0004315

Quick Facts

SNOMED CT
702444009
UMLS CUI
C1328840
Fully Specified Name
Autoimmune lymphoproliferative syndrome (disorder)
Specialists
0
Diagnostic Biomarkers
0
HPO Phenotypes
30
Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.