Autosomal dominant spastic paraplegia type 12

disorder

SNOMED 763374004CUI C1858106

Overview

Autosomal dominant spastic paraplegia type 12 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Degeneration of the lateral corticospinal tracts

Very frequent (80-99%)HP:0002314

Gait disturbance

Very frequent (80-99%)HP:0001288

Increased reflexes

Very frequent (80-99%)HP:0001347

Lower limb muscle weakness

Very frequent (80-99%)HP:0007340

Progressive spastic paraplegia

Very frequent (80-99%)HP:0007020

Spasticity of lower limb

Very frequent (80-99%)HP:0002061

Appendicular ataxia

Frequent (30-79%)HP:0002070

Cavus foot

Frequent (30-79%)HP:0001761

Clonus

Frequent (30-79%)HP:0002169

Distal sensory loss, especially vibratory sense

Frequent (30-79%)HP:0002166

Extensor plantar responses

Frequent (30-79%)HP:0003487

Female sexual dysfunction

Frequent (30-79%)HP:0030014

Impaired proprioception

Frequent (30-79%)HP:0010831

Lower limb amyotrophy

Frequent (30-79%)HP:0007210

Male sexual dysfunction

Frequent (30-79%)HP:0040307

Muscle spasm

Frequent (30-79%)HP:0003394

Spastic walk

Frequent (30-79%)HP:0002064

Spinal cord lesion

Frequent (30-79%)HP:0100561

Urgency frequency syndrome

Frequent (30-79%)HP:0000012

Urinary incontinence

Frequent (30-79%)HP:0000020

Anal incontinence

Occasional (5-29%)HP:0002607

Upper limb hyperreflexia

Occasional (5-29%)HP:0007350

Ankle clonus

HP:0011448

Knee clonus

HP:0011449

Spastic paraplegia

HP:0001258

Sphincter disturbances

HP:0002839

Related Conditions

Pure hereditary spastic paraplegia(parent)

Autosomal dominant hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 763374004
UMLS CUI: C1858106
Fully Specified Name: Autosomal dominant spastic paraplegia type 12 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 26

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.