Autosomal dominant spastic paraplegia type 73

disorder

SNOMED 1187468005CUI C5568981

Overview

Autosomal dominant spastic paraplegia type 73 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Decreased distal vibration sense

Always present (100%)HP:0006886

Neurogenic muscle atrophy, especially in the lower limbs

Always present (100%)HP:0003202

Prolonged central motor conduction time

Always present (100%)HP:0034399

Proximal limb muscle weakness

Always present (100%)HP:0003701

Spastic paraplegia

Always present (100%)HP:0001258

Degeneration of the lateral corticospinal tracts

Very frequent (80-99%)HP:0002314

Extensor plantar responses

Very frequent (80-99%)HP:0003487

Increased reflexes

Very frequent (80-99%)HP:0001347

Progressive spastic paraplegia

Very frequent (80-99%)HP:0007020

Spastic walk

Very frequent (80-99%)HP:0002064

Spasticity of lower limb

Very frequent (80-99%)HP:0002061

Abnormal electromyography finding

Frequent (30-79%)HP:0003457

Abnormal motor evoked potentials in the lower limb

Frequent (30-79%)HP:0012898

Claw toe deformity

Frequent (30-79%)HP:0034397

Distal muscle weakness in lower limbs

Frequent (30-79%)HP:0009053

Distal sensory loss, especially vibratory sense

Frequent (30-79%)HP:0002166

Gait disturbance

Frequent (30-79%)HP:0001288

Lower limb muscle hypotrophy

Frequent (30-79%)HP:0008944

Progressive spastic paraparesis

Frequent (30-79%)HP:0007199

Urgency frequency syndrome

Frequent (30-79%)HP:0000012

Urinary incontinence

Frequent (30-79%)HP:0000020

Pes cavus

Occasional (5-29%)HP:0001761

Related Conditions

Pure hereditary spastic paraplegia(parent)

Autosomal dominant hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 1187468005
UMLS CUI: C5568981
Fully Specified Name: Autosomal dominant spastic paraplegia type 73 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 22

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.