Autosomal recessive spastic paraplegia type 21

disorder

SNOMED 764734003CUI C1855346

Overview

Autosomal recessive spastic paraplegia type 21 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Cerebral atrophy

Always present (100%)HP:0002059

Difficulty articulating speech

Always present (100%)HP:0001260

Extensor plantar responses

Always present (100%)HP:0003487

Infratentorial atrophy

Always present (100%)HP:0001272

Periventricular white matter hyperintensities

Always present (100%)HP:0030891

Spasticity and rigidity of muscles

Always present (100%)HP:0001276

Thinning of the corpus callosum

Always present (100%)HP:0033725

Corticospinal signs

Very frequent (80-99%)HP:0007256

Gait disturbance

Very frequent (80-99%)HP:0001288

No development of motor milestones

Very frequent (80-99%)HP:0001270

Progressive dementia

Very frequent (80-99%)HP:0000726

Abnormal peripheral nerve transmission

Frequent (30-79%)HP:0003134

Agraphia

Frequent (30-79%)HP:0010526

Apraxia

Frequent (30-79%)HP:0002186

Archaic reflex

Frequent (30-79%)HP:0002476

Deglutition disorder

Frequent (30-79%)HP:0002015

Frontotemporal cerebral atrophy

Frequent (30-79%)HP:0006892

Hypoplasia of corpus callosum

Frequent (30-79%)HP:0002079

Increased reflexes

Frequent (30-79%)HP:0001347

Intellectual deterioration

Frequent (30-79%)HP:0001268

Involuntary muscle stiffness, contraction, or spasm

Frequent (30-79%)HP:0001257

Jaw hyperreflexia

Frequent (30-79%)HP:0033683

Lower limb muscle weakness

Frequent (30-79%)HP:0007340

Mental and motor retardation

Frequent (30-79%)HP:0001263

Personality disorder

Frequent (30-79%)HP:0012075

Athetoid movements

Occasional (5-29%)HP:0002305

Cerebellar signs

Occasional (5-29%)HP:0001317

Extrapyramidal dysfunction

Occasional (5-29%)HP:0002071

Neuropathy

Occasional (5-29%)HP:0009830

Akinetic mutism

HP:0012672

Related Conditions

Complicated hereditary spastic paraplegia(parent)

Autosomal recessive hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 764734003
UMLS CUI: C1855346
Fully Specified Name: Autosomal recessive spastic paraplegia type 21 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.