Autosomal recessive spastic paraplegia type 26

disorder

SNOMED 726607007CUI C1836632

Overview

Autosomal recessive spastic paraplegia type 26 is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Mental retardation, mild

Always present (100%)HP:0001256

Lower limb muscle weakness

Very frequent (80-99%)HP:0007340

Cerebral cortex atrophy

Frequent (30-79%)HP:0002120

Difficulty articulating speech

Frequent (30-79%)HP:0001260

Extensor plantar responses

Frequent (30-79%)HP:0003487

Gait disturbance

Frequent (30-79%)HP:0001288

Hyperintensity of cerebral white matter on MRI

Frequent (30-79%)HP:0030890

Impaired vibratory sensation

Frequent (30-79%)HP:0002495

Increased reflexes

Frequent (30-79%)HP:0001347

Lower limb atrophy

Frequent (30-79%)HP:0008944

Muscle degeneration

Frequent (30-79%)HP:0003202

Muscle weakness

Frequent (30-79%)HP:0001324

Nerve damage causing decreased feeling and movement

Frequent (30-79%)HP:0007141

Nonprogressive mental retardation

Frequent (30-79%)HP:0001249

Spasticity of lower limb

Frequent (30-79%)HP:0002061

Upper extremity spasticity

Frequent (30-79%)HP:0006986

Abnormality of the urinary system

Occasional (5-29%)HP:0000079

Cavus foot

Occasional (5-29%)HP:0001761

Cerebellar abnormality

Occasional (5-29%)HP:0001317

Cobb angle greater than ten degrees

Occasional (5-29%)HP:0002650

Decreased vibration sense in feet

Occasional (5-29%)HP:0006938

Dyskinesia

Occasional (5-29%)HP:0100660

Dystonic disease

Occasional (5-29%)HP:0001332

Involuntary, rapid, rhythmic eye movements

Occasional (5-29%)HP:0000639

Lens opacities

Occasional (5-29%)HP:0000518

Posterior capsular cataract

Occasional (5-29%)HP:0100020

Pseudobulbar palsy

Occasional (5-29%)HP:0007024

Upper limb muscle weakness

Occasional (5-29%)HP:0003484

Urinary urgency

Occasional (5-29%)HP:0000012

Decreased serum testosterone level

Very rare (1-4%)HP:0040171

Related Conditions

Complicated hereditary spastic paraplegia(parent)

Autosomal recessive hereditary spastic paraplegia(parent)

Quick Facts

SNOMED CT: 726607007
UMLS CUI: C1836632
Fully Specified Name: Autosomal recessive spastic paraplegia type 26 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.