Congenital facial diplegia

disorder

SNOMED 766987006CUI C0221060

Overview

Congenital facial diplegia is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Research Evidence

Peer-reviewed studies linked via MeSH term "Mobius Syndrome" from the MEDLINE/PubMed database.

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Oral findings and comprehensive dental management of Moebius syndrome: a systematic review.

[object Object], [object Object], [object Object] et al. · BMC Oral Health · 2024

PMID: 38321523Meta-AnalysisFull text (PMC)

A Systematic Review of the Psychosocial Adjustment of Children and Adolescents with Facial Palsy: The Impact of Moebius Syndrome.

[object Object], [object Object], [object Object] et al. · Int J Environ Res Public Health · 2020

PMID: 32751746Meta-AnalysisFull text (PMC)

Will the real Moebius syndrome please stand up? A systematic review of the literature and statistical cluster analysis of clinical features.

[object Object], [object Object], [object Object] et al. · Am J Med Genet A · 2019

PMID: 30556292Meta-Analysis

Prenatal exposure to misoprostol and congenital anomalies: systematic review and meta-analysis.

[object Object], [object Object], [object Object] · Reprod Toxicol · 2006

PMID: 16750609Meta-Analysis

The localization of facial motor impairment in sporadic Möbius syndrome.

[object Object], [object Object], [object Object] et al. · Neurology · 2006

PMID: 16801658RCT

The Etiology of Moebius Syndrome-Making the Case for Animal Models.

[object Object], [object Object], [object Object] et al. · Int J Mol Sci · 2025

PMID: 40362454ReviewFull text (PMC)

Physiopathologic Bases of Moebius Syndrome: Combining Genetic, Vascular, and Teratogenic Theories.

[object Object], [object Object], [object Object] et al. · Pediatr Neurol · 2024

PMID: 38306744Review

Echoencephalography of Möbius sequence: A congenital cranial dysinnervation disorder with brainstem calcifications.

[object Object], [object Object], [object Object] · J Neuroimaging · 2023

PMID: 36349559Review

Poland-Möbius syndrome: a case report implicating a novel mutation of the PLXND1 gene and literature review.

[object Object], [object Object], [object Object] et al. · BMC Pediatr · 2022

PMID: 36581828ReviewFull text (PMC)

Divergent roles of Plexin D1 in cancer.

[object Object], [object Object] · Biochim Biophys Acta Rev Cancer · 2019

PMID: 31152824ReviewFull text (PMC)

Search all PubMed articles for Congenital facial diplegia

Research data from MEDLINE/PubMed

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Thumb clasp

Always present (100%)HP:0001188

Cranial nerve paralysis

Very frequent (80-99%)HP:0006824

Eye drop

Very frequent (80-99%)HP:0000508

Eye muscle paralysis

Very frequent (80-99%)HP:0000602

Facial palsy

Very frequent (80-99%)HP:0010628

Feeding difficulties in infancy

Very frequent (80-99%)HP:0008872

Mask-like facies

Very frequent (80-99%)HP:0000298

Slack jawed appearance

Very frequent (80-99%)HP:0000194

Squint

Very frequent (80-99%)HP:0000486

Voice abnormality

Very frequent (80-99%)HP:0001608

Absent pectoralis major muscle

Frequent (30-79%)HP:0009751

Corneal opacity

Frequent (30-79%)HP:0007957

Deglutition disorder

Frequent (30-79%)HP:0002015

Delayed motor milestones

Frequent (30-79%)HP:0001270

Eclabium of lower lip

Frequent (30-79%)HP:0000232

Fetal foot inversion

Frequent (30-79%)HP:0001762

Hypoplastic mandible condyle

Frequent (30-79%)HP:0000347

Peripheral hypotonia

Frequent (30-79%)HP:0001252

Speech difficulties

Frequent (30-79%)HP:0000750

Tooth abnormalities

Frequent (30-79%)HP:0000164

Abnormal morphology of ulna

Occasional (5-29%)HP:0040071

Abnormality of the sense of smell

Occasional (5-29%)HP:0004408

Absent hand

Occasional (5-29%)HP:0004050

Absent/underdeveloped radius

Occasional (5-29%)HP:0006501

Aplasia/Hypoplasia of the tongue

Occasional (5-29%)HP:0010295

Aplastic/hypoplastic thumbs

Occasional (5-29%)HP:0009601

Arthrogryposis multiplex

Occasional (5-29%)HP:0002804

Autism

Occasional (5-29%)HP:0000717

Blepharitis

Occasional (5-29%)HP:0000498

Cleft of palate

Occasional (5-29%)HP:0000175

Related Conditions

Hereditary disorder of nervous system(parent)

Autosomal dominant hereditary disorder(parent)

Congenital facial nerve palsy(parent)

Congenital sixth nerve palsy(parent)

Hereditary disorder of the visual system(parent)

Quick Facts

SNOMED CT: 766987006
UMLS CUI: C0221060
Fully Specified Name: Moebius syndrome (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.