Congenital plasminogen activator inhibitor deficiency type 1

disorder

SNOMED 717407006CUI C4273899

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Decreased level of tissue plasminogen activator

Very frequent (80-99%)HP:0040230

Excessive bleeding after minor trauma

Very frequent (80-99%)HP:0001934

Hypoplasminogenemia

Very frequent (80-99%)HP:0040228

Protracted bleeding after surgery

Very frequent (80-99%)HP:0004846

Reduced alpha-2-antiplasmin activity

Very frequent (80-99%)HP:0040245

Reduced plasminogen activator inhibitor 1 activity

Very frequent (80-99%)HP:0040248

Reduced plasminogen activator inhibitor 1 antigen

Very frequent (80-99%)HP:0040249

Bleeding below the skin

Frequent (30-79%)HP:0001933

Hypermenorrhea

Frequent (30-79%)HP:0000132

Premature birth

Frequent (30-79%)HP:0001622

Frequent nosebleeds

Occasional (5-29%)HP:0000421

Gastrointestinal haemorrhage

Occasional (5-29%)HP:0002239

Intracranial haemorrhage

Occasional (5-29%)HP:0002170

Oral bleeding

Occasional (5-29%)HP:0040184

Post-partum hemorrhage

Occasional (5-29%)HP:0011891

Prolonged bleeding after dental extraction

Occasional (5-29%)HP:0006298

Umbilical cord hematoma

Occasional (5-29%)HP:0030657

Epidural hematoma

Very rare (1-4%)HP:0100310

Hemoperitoneum

Very rare (1-4%)HP:0011854

Intramuscular haematoma

Very rare (1-4%)HP:0012233

Joint hemorrhage

Very rare (1-4%)HP:0005261

Myocardial fibrosis

Very rare (1-4%)HP:0001685

Poor wound healing

Very rare (1-4%)HP:0001058

Related Conditions

Hereditary coagulation factor deficiency(parent)

Congenital disease(parent)

Recessive hereditary disorder (autosomal)(parent)

Quick Facts

SNOMED CT: 717407006
UMLS CUI: C4273899
Fully Specified Name: Congenital plasminogen activator inhibitor deficiency type 1 (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 23

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.