Research Evidence
Peer-reviewed studies linked via MeSH term "Dent Disease" from the MEDLINE/PubMed database.
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Dent disease: clinical practice recommendations.
[object Object], [object Object], [object Object] et al. · Nephrol Dial Transplant · 2025
Tubular proteinuria due to hereditary endocytic receptor disorder of the proximal tubule: Dent disease and chronic benign proteinuria.
[object Object], [object Object] · Pediatr Nephrol · 2025
Dent disease: classification, heterogeneity and diagnosis.
[object Object], [object Object], [object Object] et al. · World J Pediatr · 2021
PMID: 32248351Review
Genetics and phenotypic heterogeneity of Dent disease: the dark side of the moon.
[object Object], [object Object], [object Object] et al. · Hum Genet · 2021
From protein uptake to Dent disease: An overview of the CLCN5 gene.
[object Object], [object Object], [object Object] et al. · Gene · 2020
Making a Dent in Dent Disease.
[object Object], [object Object] · Function (Oxf) · 2020
Dent disease: A window into calcium and phosphate transport.
[object Object], [object Object], [object Object] et al. · J Cell Mol Med · 2019
Update on Dent Disease.
[object Object], [object Object] · Pediatr Clin North Am · 2019
PMID: 30454742Review
Congenital and acquired diseases related to stone formation.
[object Object], [object Object], [object Object] · Curr Opin Urol · 2018
PMID: 29957682Review
Clinical Approach to Proximal Renal Tubular Acidosis in Children.
[object Object], [object Object] · Adv Chronic Kidney Dis · 2018
PMID: 30139461Review
Search all PubMed articles for Dent disease
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Abnormal urinary amino-acid findings
Very frequent (80-99%)HP:0003355
Blood in urine
Very frequent (80-99%)HP:0000790
CKD
Very frequent (80-99%)HP:0012622
Focal and segmental glomerulosclerosis
Very frequent (80-99%)HP:0000097
Glucose in urine
Very frequent (80-99%)HP:0003076
High urine phosphate levels
Very frequent (80-99%)HP:0003109
High urine uric acid level
Very frequent (80-99%)HP:0003149
Hypercalciuria
Very frequent (80-99%)HP:0002150
Increased fracture rate
Very frequent (80-99%)HP:0002757
Increased serum calcitriol
Very frequent (80-99%)HP:0031415
Kidney stones
Very frequent (80-99%)HP:0000787
Low-molecular-weight proteinuria
Very frequent (80-99%)HP:0003126
Non-acidotic proximal tubulopathy
Very frequent (80-99%)HP:0005574
Proteinuria
Very frequent (80-99%)HP:0000093
Renal failure
Very frequent (80-99%)HP:0000083
Renal hypophosphatemia
Very frequent (80-99%)HP:0008732
Renal tubular cell atrophy
Very frequent (80-99%)HP:0000092
Selective proximal tubular damage
Very frequent (80-99%)HP:0000114
Tubular phosphate reabsorption low
Very frequent (80-99%)HP:0000117
Tubulointerstitial scarring
Very frequent (80-99%)HP:0005576
Bone pain
Frequent (30-79%)HP:0002653
Elevated serum creatine phosphokinase
Frequent (30-79%)HP:0003236
Nephrocalcinosis
Frequent (30-79%)HP:0000121
Stomach pain
Frequent (30-79%)HP:0002027
Abnormality of the lower limb
Occasional (5-29%)HP:0002814
Bowed lower limbs
Occasional (5-29%)HP:0002979
Bulging epiphyses
Occasional (5-29%)HP:0003013
Cataract
Occasional (5-29%)HP:0000518
Enlargement of the ankles
Occasional (5-29%)HP:0003029
Enlargement of the wrists
Occasional (5-29%)HP:0003020
Quick Facts
- SNOMED CT
- 444645005
- UMLS CUI
- C0878681
- Fully Specified Name
- Dent's disease (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.