Treatments & Interventions
Research Evidence
Peer-reviewed studies linked via MeSH term "Lennox Gastaut Syndromes" from the MEDLINE/PubMed database.
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Comparative efficacy of neuromodulation therapies in Lennox-Gastaut syndrome: A systematic review and meta-analysis of vagus nerve stimulation, deep brain stimulation, and responsive neurostimulation.
[object Object], [object Object], [object Object] et al. · Epilepsia · 2025
PMID: 40657941Meta-Analysis
Effectiveness and safety of perampanel in Lennox-Gastaut syndrome: a GRADE-assessed systematic review and meta-analysis.
[object Object], [object Object], [object Object] et al. · Naunyn Schmiedebergs Arch Pharmacol · 2025
PMID: 40613940Meta-Analysis
Antiseizure medications in CDKL5 encephalopathy- systematic review.
[object Object], [object Object], [object Object] · Seizure · 2025
PMID: 40834685Meta-Analysis
Efficacy and safety of six new antiseizure medications for adjunctive treatment of focal epilepsy and epileptic syndrome: A systematic review and network meta-analysis.
[object Object], [object Object], [object Object] et al. · Epilepsy Behav · 2024
PMID: 38277848Meta-Analysis
A systematic literature review on the global epidemiology of Dravet syndrome and Lennox-Gastaut syndrome: Prevalence, incidence, diagnosis, and mortality.
[object Object], [object Object], [object Object] et al. · Epilepsia · 2024
PMID: 38252068Meta-Analysis
A systematic review of electroencephalographic findings in Lennox-Gastaut syndrome.
[object Object], [object Object], [object Object] · Epilepsy Res · 2024
PMID: 38976954Meta-Analysis
A comprehensive systematic literature review of the burden of illness of Lennox-Gastaut syndrome on patients, caregivers, and society.
[object Object], [object Object], [object Object] et al. · Epilepsia · 2024
PMID: 38456647Meta-Analysis
The efficacy and safety of cannabidiol (CBD) in pediatric patients with Dravet Syndrome: a narrative review of clinical trials.
[object Object], [object Object], [object Object] et al. · Eur J Med Res · 2024
The burden of illness in Lennox-Gastaut syndrome: a systematic literature review.
[object Object], [object Object], [object Object] et al. · Orphanet J Rare Dis · 2023
Callosotomy vs Vagus Nerve Stimulation in the Treatment of Lennox-Gastaut Syndrome: A Systematic Review With Meta-Analysis.
[object Object], [object Object] · Neuromodulation · 2023
PMID: 35989160Meta-Analysis
Search all PubMed articles for Lennox-Gastaut syndrome
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
EEG with focal sharp slow waves
Very frequent (80-99%)HP:0011195
Encephalopathy
Very frequent (80-99%)HP:0001298
Nonprogressive mental retardation
Very frequent (80-99%)HP:0001249
Abnormality of brainstem morphology
Frequent (30-79%)HP:0002363
Aggression
Frequent (30-79%)HP:0000718
Atypical absence
Frequent (30-79%)HP:0007270
Autism spectrum disorder
Frequent (30-79%)HP:0000729
Behavioural/Psychiatric abnormality
Frequent (30-79%)HP:0000708
Electroencephalogram abnormal
Frequent (30-79%)HP:0002353
Falls
Frequent (30-79%)HP:0002527
Generalised tonic seizures
Frequent (30-79%)HP:0010818
Generalized tonic-clonic seizure (without specification of onset)
Frequent (30-79%)HP:0002069
hyperkinetic disorder
Frequent (30-79%)HP:0000752
Intellectual deterioration
Frequent (30-79%)HP:0001268
Irritable mood
Frequent (30-79%)HP:0000737
Jerking
Frequent (30-79%)HP:0001336
Neurodevelopmental delay
Frequent (30-79%)HP:0012758
Personality disorder
Frequent (30-79%)HP:0012075
Sudden loss of muscle tone
Frequent (30-79%)HP:0010819
Focal seizures
Occasional (5-29%)HP:0007359
Generalized myoclonic seizure
Occasional (5-29%)HP:0002123
Lack of feeling, emotion, interest
Occasional (5-29%)HP:0000741
Loss of milestones
Occasional (5-29%)HP:0002376
Psychosis
Occasional (5-29%)HP:0000709
Vertigo
Occasional (5-29%)HP:0002321
Quick Facts
- SNOMED CT
- 230418006
- UMLS CUI
- C0238111
- Fully Specified Name
- Lennox-Gastaut syndrome (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 25
- Known Treatments
- 7
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.