Macrophage activation syndrome

disorder

SNOMED 430478003CUI C1096155

Overview

Macrophage activation syndrome is a disorder.

Auto-generated from clinical reference data. Not a substitute for medical advice.

Research Evidence

Peer-reviewed studies linked via MeSH term "Syndrome, Macrophage Activation" from the MEDLINE/PubMed database.

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Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project.

[object Object], [object Object], [object Object] et al. · Rheumatology (Oxford) · 2025

PMID: 39058514Meta-AnalysisFull text (PMC)

Systemic juvenile idiopathic arthritis and adult-onset Still's disease are the same disease: evidence from systematic reviews and meta-analyses informing the 2023 EULAR/PReS recommendations for the diagnosis and management of Still's disease.

[object Object], [object Object], [object Object] et al. · Ann Rheum Dis · 2024

PMID: 39317414Meta-AnalysisFull text (PMC)

Eighty-six cases of clinical characteristics and outcomes of systemic lupus erythematosus-associated macrophage activation syndrome: A meta-analysis study.

[object Object], [object Object], [object Object] · Immun Inflamm Dis · 2024

PMID: 39110110Meta-AnalysisFull text (PMC)

Neonatal hemophagocytic lymphohistiocytosis: A meta-analysis of 205 cases.

[object Object], [object Object], [object Object] et al. · Pediatr Blood Cancer · 2024

PMID: 38296838Meta-Analysis

Efficacy and safety of therapies for Still's disease and macrophage activation syndrome (MAS): a systematic review informing the EULAR/PReS guidelines for the management of Still's disease.

[object Object], [object Object], [object Object] et al. · Ann Rheum Dis · 2024

PMID: 39317415Meta-AnalysisFull text (PMC)

Immunopathology of and potential therapeutics for secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome: a translational perspective.

[object Object], [object Object], [object Object] et al. · Exp Mol Med · 2024

PMID: 38448692Meta-AnalysisFull text (PMC)

Intravenous anakinra for the treatment of haemophagocytic lymphohistiocytosis/macrophage activation syndrome: A systematic review.

[object Object], [object Object] · Eur J Haematol · 2023

PMID: 37344166Meta-Analysis

The 2022 EULAR/ACR points to consider at the early stages of diagnosis and management of suspected haemophagocytic lymphohistiocytosis/macrophage activation syndrome (HLH/MAS).

[object Object], [object Object], [object Object] et al. · Ann Rheum Dis · 2023

PMID: 37487610Meta-AnalysisFull text (PMC)

The 2022 EULAR/ACR Points to Consider at the Early Stages of Diagnosis and Management of Suspected Haemophagocytic Lymphohistiocytosis/Macrophage Activation Syndrome (HLH/MAS).

[object Object], [object Object], [object Object] et al. · Arthritis Rheumatol · 2023

PMID: 37486733Meta-AnalysisFull text (PMC)

Bibliometrics analysis on the research status and trends of adult-onset Still's disease: 1921-2021.

[object Object], [object Object], [object Object] et al. · Front Immunol · 2022

PMID: 35924251Meta-AnalysisFull text (PMC)

Search all PubMed articles for Macrophage activation syndrome

Research data from MEDLINE/PubMed

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Abnormal total natural killer cell count

Very frequent (80-99%)HP:0040089

Abnormality of cachexin secretion

Very frequent (80-99%)HP:0011118

Abnormality of interleukin secretion

Very frequent (80-99%)HP:0011117

Alanine aminotransferase increased

Very frequent (80-99%)HP:0031964

Autoimmune disorder

Very frequent (80-99%)HP:0002960

Elevated sedimentation rate

Very frequent (80-99%)HP:0003565

Hemophagocytosis

Very frequent (80-99%)HP:0012156

Hypoalbuminaemia

Very frequent (80-99%)HP:0003073

Increased circulating interferon-gamma concentration

Very frequent (80-99%)HP:0030356

Increased circulating interleukin 6 concentration

Very frequent (80-99%)HP:0030783

Increased inflammatory response

Very frequent (80-99%)HP:0012649

Increased lactate dehydrogenase level

Very frequent (80-99%)HP:0025435

Increased serum ferritin level

Very frequent (80-99%)HP:0003281

Liver dysfunction, mild

Very frequent (80-99%)HP:0001410

Low number of red blood cells or hemoglobin

Very frequent (80-99%)HP:0001903

Pyrexia

Very frequent (80-99%)HP:0001945

Thrombocytopenia

Very frequent (80-99%)HP:0001873

Elevated C-reactive protein level

Frequent (30-79%)HP:0011227

Elevated serum aspartate aminotransferase

Frequent (30-79%)HP:0031956

Increased triglycerides

Frequent (30-79%)HP:0002155

Juvenile rheumatoid arthritis

Frequent (30-79%)HP:0005681

Large spleen

Frequent (30-79%)HP:0001744

Low fibrinogen level

Frequent (30-79%)HP:0011900

Lymph node hyperplasia

Frequent (30-79%)HP:0002716

Neutropoenia

Frequent (30-79%)HP:0001875

Encephalopathy

Occasional (5-29%)HP:0001298

Enlarged liver

Occasional (5-29%)HP:0002240

Hepatitis

Occasional (5-29%)HP:0012115

SLE

Occasional (5-29%)HP:0002725

Related Conditions

Macrophage activation syndrome due to juvenile systemic onset arthritis(child)

Periodic fever, infantile enterocolitis, autoinflammatory syndrome(child)

Macrophage activation syndrome due to infectious disease(child)

Haemophagocytic lymphohistiocytosis(parent)

Quick Facts

SNOMED CT: 430478003
UMLS CUI: C1096155
Fully Specified Name: Macrophage activation syndrome (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 29

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.