Clinical Trials
4
Total Trials
2
Recruiting
0
With Results
Recent Trials
Feasibility and Tolerability of IMLYGIC for the Treatment of Cutaneous Neurofibromas in Adults With NF1
NCT07102394Phase 1Recruiting10 enrolled
Natural History Study of Patients With Neurofibromatosis Type I
NCT00924196Active Not Recruiting259 enrolled
Study of Disease Severity in Adults With Neurofibromatosis Type 1 (NF1)
NCT00111384Completed313 enrolled
Natural History and Biology of Skin Neurofibromas in Neurofibromatosis Type 1
NCT00314119Completed17 enrolled
Research Evidence
Peer-reviewed studies linked via MeSH term "Neurofibroma" from the MEDLINE/PubMed database.
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A core outcome domain set to assess cutaneous neurofibromas related to neurofibromatosis type 1 in clinical trials.
[object Object], [object Object], [object Object] et al. · Br J Dermatol · 2024
PMID: 37877514Meta-Analysis
Hybrid tumors with perineurioma components: a systematic review of the literature and illustrative case.
[object Object], [object Object], [object Object] et al. · Acta Neurochir (Wien) · 2023
Patient demographics, tumor characteristics, and outcomes following surgical treatment of benign and malignant brachial plexus tumors: a systematic review.
[object Object], [object Object] · Int J Surg · 2023
Isolated, Nonsyndromic Mucocutaneous Plexiform Neurofibromas: A Systematic Review of the Clinicopathologic Features.
[object Object], [object Object], [object Object] et al. · Am J Dermatopathol · 2022
PMID: 36395447Meta-Analysis
Low mutation burden and frequent loss of CDKN2A/B and SMARCA2, but not PRC2, define premalignant neurofibromatosis type 1-associated atypical neurofibromas.
[object Object], [object Object], [object Object] et al. · Neuro Oncol · 2019
Pacinian neuromas and neurofibromas of the hands and fingers: a systematic review.
[object Object], [object Object], [object Object] et al. · J Hand Surg Eur Vol · 2019
PMID: 31156019Meta-Analysis
Prevalence and clinicopathological characteristics of lipomatous neurofibromas in neurofibromatosis 1: An investigation of 229 cutaneous neurofibromas and a systematic review of the literature.
[object Object], [object Object], [object Object] et al. · J Cutan Pathol · 2018
PMID: 29959804Meta-Analysis
Radiation-Induced Schwannomas and Neurofibromas: A Systematic Review.
[object Object], [object Object] · World Neurosurg · 2017
PMID: 28532923Meta-Analysis
Gene signature associated with benign neurofibroma transformation to malignant peripheral nerve sheath tumors.
[object Object], [object Object], [object Object] et al. · PLoS One · 2017
Effect of NFX-179 MEK inhibitor on cutaneous neurofibromas in persons with neurofibromatosis type 1.
[object Object], [object Object], [object Object] et al. · Sci Adv · 2024
Search all PubMed articles for Neurofibroma
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Neurofibroma
Always present (100%)HP:0001067
Enlarged peripheral nerve
Frequent (30-79%)HP:0012645
Periarticular subcutaneous nodules
Frequent (30-79%)HP:0007470
Plexiform neurofibroma
Frequent (30-79%)HP:0009732
Subcutaneous neurofibroma
Frequent (30-79%)HP:0100698
Abnormality of the cranial nerves
Occasional (5-29%)HP:0001291
Paraspinal neurofibroma
Occasional (5-29%)HP:0006751
Peripheral nerve compression
Occasional (5-29%)HP:0003406
Spinal neurofibroma
Occasional (5-29%)HP:0009735
Spinal stenosis
Occasional (5-29%)HP:0003416
Symmetric spinal nerve root neurofibromas
Occasional (5-29%)HP:0006851
Anomaly of the biliary tract
Very rare (1-4%)HP:0012440
Atypical neurofibromatosis
Very rare (1-4%)HP:0007524
Face tumour
Very rare (1-4%)HP:0012289
Hyperplasia of parotid gland
Very rare (1-4%)HP:0011801
Intestinal bleeding
Very rare (1-4%)HP:0002584
Kyphoscoliosis
Very rare (1-4%)HP:0002751
Large head
Very rare (1-4%)HP:0000256
Multiple intestinal neurofibromatosis
Very rare (1-4%)HP:0005220
Neoplasia of the pleura
Very rare (1-4%)HP:0100527
Palmar neurofibromas
Very rare (1-4%)HP:0007576
Peripheral schwannoma
Very rare (1-4%)HP:0009593
Recurrent middle ear infection
Very rare (1-4%)HP:0000403
Spinal meningioma
Very rare (1-4%)HP:0100010
Tracheal neoplasm
Very rare (1-4%)HP:0100551
Tumours of the breast
Very rare (1-4%)HP:0100013
Related Conditions
Neuroma cutis(child)
Diffuse neurofibroma(child)
Solitary neurofibroma(child)
Myxoid neurofibroma(child)
Epithelioid neurofibroma(child)
Neurofibroma of subcutaneous tissue(child)
Neurofibroma of upper limb(child)
Neurofibroma of lower limb(child)
Neurofibroma of trunk(child)
Neurofibroma of neck(child)
Neurofibroma of head(child)
Plexiform neurofibroma(child)
Atypical neurofibroma(child)
Cellular neurofibroma(child)
Benign neoplasm of nerve sheath origin(parent)
Quick Facts
- SNOMED CT
- 404029005
- UMLS CUI
- C0027830
- Fully Specified Name
- Neurofibroma (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 26
- Clinical Trials
- 4
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.