Overview
Polyostotic sclerosing histiocytosis is a disorder.
Auto-generated from clinical reference data. Not a substitute for medical advice.
Research Evidence
Peer-reviewed studies linked via MeSH term "Erdheim-Chester Disease" from the MEDLINE/PubMed database.
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Radiological assessment of extremity bone involvement in Erdheim-Chester disease: a systematic review of case reports.
[object Object], [object Object], [object Object] et al. · Skeletal Radiol · 2025
PMID: 39652116Meta-Analysis
Hypophysitis: A comprehensive overview.
[object Object], [object Object], [object Object] et al. · Presse Med · 2021
PMID: 34687912Meta-Analysis
Skull Base Manifestations of Erdheim-Chester Disease: A Case Series and Systematic Review.
[object Object], [object Object], [object Object] et al. · Neurosurgery · 2019
PMID: 30828728Meta-Analysis
When flames hit the brain, and the spark is far away: the role of PET-CT in diagnosing neurological Erdheim-Chester disease.
[object Object], [object Object], [object Object] et al. · Arq Neuropsiquiatr · 2025
Updates on Langerhans cell histiocytosis and other histiocytosis in children: invited review-challenges and novelties in paediatric tumours.
[object Object], [object Object] · Virchows Arch · 2025
PMID: 39794638Review
Neuroimaging Spectrum of Erdheim-Chester Disease: An Image-Based Review.
[object Object], [object Object], [object Object] et al. · AJNR Am J Neuroradiol · 2025
Approach to the Patient: From Endocrinopathy to the Diagnosis of a Histiocytic Disorder.
[object Object], [object Object], [object Object] et al. · J Clin Endocrinol Metab · 2025
Recent advances in therapeutic strategies of Erdheim-Chester disease.
[object Object], [object Object], [object Object] et al. · Naunyn Schmiedebergs Arch Pharmacol · 2025
PMID: 39836251Review
Erdheim-Chester disease: Comprehensive insights from genetic mutations to clinical manifestations and therapeutic advances.
[object Object], [object Object], [object Object] et al. · Dis Mon · 2025
PMID: 39757048Review
Decoding Erdheim-Chester Disease: a Pictorial Essay of the Radiologic and Pathologic Findings, and its Main Differential Diagnoses.
[object Object], [object Object], [object Object] et al. · Clin Radiol · 2025
PMID: 40215805Review
Search all PubMed articles for Polyostotic sclerosing histiocytosis
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Abnormal metaphysis morphology
Very frequent (80-99%)HP:0000944
Anomaly of the epiphyses
Very frequent (80-99%)HP:0005930
Bone infection
Very frequent (80-99%)HP:0002754
Bone pain
Very frequent (80-99%)HP:0002653
Breakdown of bone
Very frequent (80-99%)HP:0002797
Diabetes insipidus
Very frequent (80-99%)HP:0000873
Extreme thirst
Very frequent (80-99%)HP:0001959
Hyperhidrosis
Very frequent (80-99%)HP:0000975
Increased bone mineral density
Very frequent (80-99%)HP:0011001
Isolated hypogonadotropic hypogonadism
Very frequent (80-99%)HP:0000044
Painful or difficult urination
Very frequent (80-99%)HP:0100518
Prominent globes
Very frequent (80-99%)HP:0000520
Pyrexia
Very frequent (80-99%)HP:0001945
Tiredness
Very frequent (80-99%)HP:0012378
Weight loss
Very frequent (80-99%)HP:0001824
Xanthoma
Very frequent (80-99%)HP:0001114
Abnormal aortic valve morphology
Frequent (30-79%)HP:0001646
Hydronephrosis
Frequent (30-79%)HP:0000126
Joint swelling
Frequent (30-79%)HP:0001386
Retroperitoneal fibrosis
Frequent (30-79%)HP:0005200
Stomach pain
Frequent (30-79%)HP:0002027
Abnormality of immune system physiology
Occasional (5-29%)HP:0010978
Abnormality of the pericardium
Occasional (5-29%)HP:0001697
Ataxia
Occasional (5-29%)HP:0001251
Cardiac insufficiency
Occasional (5-29%)HP:0001635
Cerebellar signs
Occasional (5-29%)HP:0001317
Coughing
Occasional (5-29%)HP:0012735
Death of bone due to decreased blood supply
Occasional (5-29%)HP:0010885
Decreased haemoglobin
Occasional (5-29%)HP:0001903
Difficulty articulating speech
Occasional (5-29%)HP:0001260
Related Conditions
Quick Facts
- SNOMED CT
- 699537002
- UMLS CUI
- C0878675
- Fully Specified Name
- Erdheim-Chester disease (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.