Progressive supranuclear ophthalmoplegia

disorder

SNOMED 28978003CUI C0038868

Overview

Source: MedlinePlus.gov, National Library of Medicine. Not a substitute for medical advice.

Signs & Symptoms

Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.

Degeneration of cerebrum

Always present (100%)HP:0002059

Increase in astrocyte number

Always present (100%)HP:0002446

Micrographia

Always present (100%)HP:0031908

Senile plaques

Always present (100%)HP:0100256

Tau-positive tangle

Always present (100%)HP:0002185

Abnormal retropulsion test

Very frequent (80-99%)HP:0002172

Abnormal synaptic transmission

Very frequent (80-99%)HP:0012535

Deglutition disorder

Very frequent (80-99%)HP:0002015

Falls

Very frequent (80-99%)HP:0002527

Impulsivity

Very frequent (80-99%)HP:0100710

Intellectual deterioration

Very frequent (80-99%)HP:0001268

Neuronal loss in CNS

Very frequent (80-99%)HP:0002529

Supranuclear ophthalmoplegia

Very frequent (80-99%)HP:0000623

Unsteady walk

Very frequent (80-99%)HP:0002317

Abnormality of balance

Frequent (30-79%)HP:0002141

Axial dystonia

Frequent (30-79%)HP:0002530

Cerebral cortex atrophy

Frequent (30-79%)HP:0002120

Cognitive deficits

Frequent (30-79%)HP:0100543

Conjunctival hyperemia

Frequent (30-79%)HP:0030953

Decreased tear secretion

Frequent (30-79%)HP:0000633

Delayed language development

Frequent (30-79%)HP:0000750

Depression

Frequent (30-79%)HP:0000716

Difficulty articulating speech

Frequent (30-79%)HP:0001260

Difficulty finding words

Frequent (30-79%)HP:0002381

Dizziness

Frequent (30-79%)HP:0002321

Emotional lability

Frequent (30-79%)HP:0000712

Excess astrocytes in brain

Frequent (30-79%)HP:0002171

Impaired saccades

Frequent (30-79%)HP:0000570

Impaired vision

Frequent (30-79%)HP:0000505

Involuntary closure of eyelid

Frequent (30-79%)HP:0000643

Related Conditions

Ophthalmoplegia(parent)

Disorder of basal ganglia(parent)

Cerebral degeneration(parent)

Extrapyramidal disease(parent)

Quick Facts

SNOMED CT: 28978003
UMLS CUI: C0038868
Fully Specified Name: Progressive supranuclear ophthalmoplegia (disorder)
Specialists: 0
Diagnostic Biomarkers: 0
HPO Phenotypes: 30

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.