Treatments & Interventions
Research Evidence
Peer-reviewed studies linked via MeSH term "Scleroderma, Systemic" from the MEDLINE/PubMed database.
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VE/VCOat ventilatory threshold and peak VOin CPET studies of patients with scleroderma-associated PAH: A systematic review and meta-analyses.
[object Object], [object Object], [object Object] et al. · Autoimmun Rev · 2026
PMID: 41130314Meta-Analysis
Exposure-Efficacy Meta-Model of Nintedanib in Adult Patients With Chronic Fibrosing Interstitial Lung Diseases.
[object Object], [object Object], [object Object] et al. · CPT Pharmacometrics Syst Pharmacol · 2026
Botulinum Toxin for Refractory Digital Ischemia and Ulcers in Systemic Sclerosis: A Systematic Review and Meta-Analysis.
[object Object], [object Object], [object Object] et al. · JAMA Dermatol · 2026
The role of prokinetics in managing gastrointestinal involvement in SSc: a systematic literature review.
[object Object], [object Object], [object Object] et al. · Rheumatology (Oxford) · 2025
The Role of Cardiac Magnetic Resonance Imaging Parameters in Prognostication of Systemic Sclerosis in Patients with Cardiac Involvement: A Systematic Review of the Literature.
[object Object], [object Object], [object Object] et al. · Acad Radiol · 2025
PMID: 39743476Meta-Analysis
Results from the international collaborative systematic literature review informing the 2023 EULAR recommendations for the treatment of systemic sclerosis.
[object Object], [object Object], [object Object] et al. · Ann Rheum Dis · 2025
PMID: 39874237Meta-Analysis
Evaluating the safety and efficacy of plasma therapy/plasmapheresis for systemic sclerosis - A comprehensive systematic review.
[object Object], [object Object], [object Object] et al. · Transfus Apher Sci · 2025
PMID: 39615258Meta-Analysis
Analysis of Retinal and Choroidal Microvasculature in Systemic Sclerosis Using Optical Coherence Tomography Angiography: A Systematic Review and Meta-Analysis.
[object Object], [object Object], [object Object] et al. · Ophthalmic Res · 2025
PMID: 39496253Meta-Analysis
A systematic review of botulinum toxin as a treatment for Raynaud's disease secondary to scleroderma.
[object Object], [object Object], [object Object] et al. · Clin Rheumatol · 2025
Doppler ultrasound, a noninvasive tool for the study of mesenteric arterial flow in systemic sclerosis: a cross-sectional study of a patient cohort with review and meta-analysis of the literature.
[object Object], [object Object], [object Object] et al. · Intern Emerg Med · 2025
Search all PubMed articles for Systemic sclerosis
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Abnormality of the gastrointestinal tract
Very frequent (80-99%)HP:0011024
Antinuclear antibodies
Very frequent (80-99%)HP:0003493
Arthritic pain
Very frequent (80-99%)HP:0002829
Cutaneous sclerotic plaque
Very frequent (80-99%)HP:0031359
Diffusely thickened skin
Very frequent (80-99%)HP:0001072
Muscle pain
Very frequent (80-99%)HP:0003326
Raynaud disease
Very frequent (80-99%)HP:0030880
Abnormal oesophagus morphology
Frequent (30-79%)HP:0002031
Abnormality of phalangeal joints of the hand
Frequent (30-79%)HP:0006261
Acral ulceration
Frequent (30-79%)HP:0006121
Anti-ACE2 antibody positivity
Frequent (30-79%)HP:0034117
Anti-angiotensin receptor type-1 antibody positivity
Frequent (30-79%)HP:0034094
Anti-B23 antibody positivity
Frequent (30-79%)HP:0034089
Anti-bicaudal D2 antibody positivity
Frequent (30-79%)HP:0034082
Anti-carbonic anhydrase II antibody positivity
Frequent (30-79%)HP:0033394
Anti-centromere protein A antibody positivity
Frequent (30-79%)HP:0034078
Anti-centromere protein B antibody positivity
Frequent (30-79%)HP:0034079
Anti-endothelin-1 type A receptor antibody positivity
Frequent (30-79%)HP:0034095
Anti-fibrillarin antibody positivity
Frequent (30-79%)HP:0034080
Anti-Ku antibody positivity
Frequent (30-79%)HP:0034088
Anti-Nor90 antibody positivity
Frequent (30-79%)HP:0034083
Anti-platelet antigen antibody positivity
Frequent (30-79%)HP:4000170
Anti-platelet derived growth factor receptor
Frequent (30-79%)HP:0034091
Anti-PM-Scl antibody positivity
Frequent (30-79%)HP:0033560
Anti-PM-Scl100 antibody positivity
Frequent (30-79%)HP:0034085
Anti-PM-Scl75 antibody positivity
Frequent (30-79%)HP:0034086
Anti-RNA-polymerase-III-autoantibody positivity
Frequent (30-79%)HP:0033038
Anti-Ro52/TRIM21 antibody positivity
Frequent (30-79%)HP:0034093
Anti-RuvBL1/2 antibody positivity
Frequent (30-79%)HP:0034090
Anti-Th/To antibody positivity
Frequent (30-79%)HP:0034081
Related Conditions
Limited systemic sclerosis(child)
Diffuse systemic sclerosis(child)
Systemic sclerosis without skin thickening(child)
Pericarditis secondary to scleroderma(child)
Lung disease with systemic sclerosis(child)
Occupational scleroderma(child)
PSS - Progressive systemic sclerosis(child)
Pediatric onset systemic sclerosis(child)
Renal involvement in scleroderma(child)
Systemic sclerosis caused by chemical(child)
Systemic disease(parent)
Scleroderma(parent)
Quick Facts
- SNOMED CT
- 89155008
- UMLS CUI
- C0036421
- Fully Specified Name
- Systemic sclerosis (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
- Known Treatments
- 9
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.