Research Evidence
Peer-reviewed studies linked via MeSH term "Whipple Disease" from the MEDLINE/PubMed database.
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Movement Disorders and Oculomotor Abnormalities in Whipple's Disease: An Updated Systematic Review.
[object Object], [object Object], [object Object] et al. · Tremor Other Hyperkinet Mov (N Y) · 2025
Whipple's disease-associated infective endocarditis: a systematic review.
[object Object], [object Object], [object Object] et al. · Infect Dis (Lond) · 2023
PMID: 37198913Meta-Analysis
Systematic review: Whipple's disease (Tropheryma whipplei infection) and its unmasking by tumour necrosis factor inhibitors.
[object Object] · Aliment Pharmacol Ther · 2015
PMID: 25693648Meta-Analysis
A systematic literature review of psychological factors and the development of late whiplash syndrome.
[object Object], [object Object], [object Object] et al. · Pain · 2008
PMID: 17570588Meta-Analysis
Management of acute whiplash: a randomized controlled trial of multidisciplinary stratified treatments.
[object Object], [object Object], [object Object] et al. · Pain · 2013
PMID: 23726933RCT
Efficacy of ceftriaxone or meropenem as initial therapies in Whipple's disease.
[object Object], [object Object], [object Object] · Gastroenterology · 2010
PMID: 19879276RCT
Neck pain in chronic whiplash syndrome treated with botulinum toxin. A double-blind, placebo-controlled clinical trial.
[object Object], [object Object], [object Object] · J Neurol · 2007
Human genetics of Whipple's disease.
[object Object], [object Object], [object Object] · Curr Opin Rheumatol · 2025
Ophthalmic manifestations of Whipple's disease.
[object Object] · Curr Opin Ophthalmol · 2024
PMID: 37830937Review
Whipple's disease: A rare disease that can be spotted by many doctors.
[object Object], [object Object], [object Object] et al. · Eur J Intern Med · 2024
PMID: 38105122Review
Search all PubMed articles for Whipple's disease
Research data from MEDLINE/PubMed
Signs & Symptoms
Based on Human Phenotype Ontology (HPO) disease-phenotype annotations.
Arthritic pain
Very frequent (80-99%)HP:0002829
Arthritis
Very frequent (80-99%)HP:0001369
Cachexia
Very frequent (80-99%)HP:0004326
Depression
Very frequent (80-99%)HP:0000716
Diarrhea
Very frequent (80-99%)HP:0002014
Intestinal malabsorption
Very frequent (80-99%)HP:0002024
Jerking
Very frequent (80-99%)HP:0001336
Psychomotor regression in infants
Very frequent (80-99%)HP:0002376
Pyrexia
Very frequent (80-99%)HP:0001945
Refusing to eat
Very frequent (80-99%)HP:0002039
Swollen lymph nodes in centre of chest
Very frequent (80-99%)HP:0100721
Tiredness
Very frequent (80-99%)HP:0012378
Upset stomach
Very frequent (80-99%)HP:0002027
Enlarged liver
Frequent (30-79%)HP:0002240
Hypotension
Frequent (30-79%)HP:0002615
Large spleen
Frequent (30-79%)HP:0001744
Muscle pain
Frequent (30-79%)HP:0003326
Pleurisy
Frequent (30-79%)HP:0002102
Trouble sleeping
Frequent (30-79%)HP:0002360
Uveitis
Frequent (30-79%)HP:0000554
Abnormal erection
Occasional (5-29%)HP:0100639
Anterior bulging of the globe of eye
Occasional (5-29%)HP:0000520
Ataxia
Occasional (5-29%)HP:0001251
Body fails to respond to insulin
Occasional (5-29%)HP:0000855
Brain inflammation
Occasional (5-29%)HP:0002383
Chest pain
Occasional (5-29%)HP:0100749
Corticospinal signs
Occasional (5-29%)HP:0007256
Coughing
Occasional (5-29%)HP:0012735
Cranial nerve paralysis
Occasional (5-29%)HP:0006824
Decreased haemoglobin
Occasional (5-29%)HP:0001903
Quick Facts
- SNOMED CT
- 41545003
- UMLS CUI
- C0023788
- Fully Specified Name
- Whipple's disease (disorder)
- Specialists
- 0
- Diagnostic Biomarkers
- 0
- HPO Phenotypes
- 30
Medical Disclaimer
This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.
Clinical content is derived from the SNOMED CT clinical ontology and curated medical knowledge graphs.