Substance / Medication

Activated charcoal

Overview

Active Ingredient
activated charcoal
RxNorm CUI
272

Indications

Actidose® with Sorbitol and Actidose®-Aqua should be used in a supervised medical facility or under the direction of a physician or poison control center. Actidose® with Sorbitol and Actidose®-Aqua are indicated in the management of many types of poisoning emergencies when a toxin has been ingested or when indicated for a limited number of systemic poisonings resulting from parenteral overdosage or when the toxin has been totally absorbed. If physiologic conditions are optimal, activated charcoa

Labeler: HF Acquisition Co LLC, DBA HealthFirstUpdated: 2020-02-19T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

There are no known absolute contraindications to the use of activated charcoal, however, it is not an equally effective adsorbent for all toxins. It should be used with caution, if at all, in patients who have ingested corrosive agents since the activated charcoal may obscure endoscopic visualizatio

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

2 trials linked to this intervention

2
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Effectiveness and abrasiveness of activated charcoal as a whitening agent: A systematic review of in vitro studies.
Tomás Dolores Bibiana Montero, Pecci-Lloret María Pilar, Guerrero-Gironés Julia · Ann Anat · 2023
PMID: 36183933Meta-Analysis
Effect of Taste Additives on the Palatability of Activated Charcoal: a Systematic Review.
Canitrot Elisabeth, Turgeon Alexis F, Moore Lynne et al. · J Med Toxicol · 2023
PMID: 37000410Meta-AnalysisFull text (PMC)
The effect of activated charcoal on drug exposure following intravenous administration: A meta-analysis.
Skov Kenneth, Graudal Niels A, Jürgens Gesche · Basic Clin Pharmacol Toxicol · 2021
PMID: 33386684Meta-Analysis
Systematic review on the use of activated charcoal for gastrointestinal decontamination following acute oral overdose.
Hoegberg Lotte C G, Shepherd Greene, Wood David M et al. · Clin Toxicol (Phila) · 2021
PMID: 34424785Meta-Analysis
The effect of activated charcoal on drug exposure in healthy volunteers: a meta-analysis.
Jürgens G, Hoegberg L C Groth, Graudal N A · Clin Pharmacol Ther · 2009
PMID: 19194372Meta-Analysis
Whitening efficacy of activated charcoal-based products: A single-blind randomized controlled clinical trial.
Ribeiro Edgar Pedreiro, Zanin Gabriela Torres, Gonçalves Andrey Emídio et al. · J Dent · 2024
PMID: 38316199RCT
Effect of Activated Charcoal on Mavacamten Pharmacokinetics in Healthy Participants.
Merali Samira, Chiang Manting, Sychterz Caroline et al. · Am J Cardiovasc Drugs · 2024
PMID: 38926266RCTFull text (PMC)
Does Mixing Activated Charcoal With Cola Improve Tolerability Without Affecting Pharmacokinetics? A Randomized Controlled Crossover Trial.
Keenan Michael, Wojcik Susan, Clemency Brian M et al. · J Emerg Nurs · 2024
PMID: 38583171RCT
Protective effect of activated charcoal against progression of chronic kidney disease: A randomized clinical study.
Rahman Waleed Khaild, Rabea Ihsan Salah, Meizel Mudhfar Mohammed · J Med Life · 2023
PMID: 38107705RCTFull text (PMC)
Effects of Increased Blood Flow Rate and Oral Activated Charcoal on the Severity of Uremic Pruritus: A Randomized Crossover Clinical Trial.
Zanganeh Mahmoud, Abbasi Ali, Khosravi Ahmad et al. · Saudi J Kidney Dis Transpl · 2023
PMID: 38146721RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Activated charcoal (substance)
SNOMED CT
32519007
UMLS CUI
C0001275
RxNorm CUI
272
Labeler
HF Acquisition Co LLC, DBA HealthFirst

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
2
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.