Substance / Medication

Adrenocorticotropic hormone

Overview

Active Ingredient
corticotropin
RxNorm CUI
376

Indications

Purified Cortrophin Gel is indicated in the following disorders: 1. Rheumatic disorders: 2. Collagen diseases: 3. Dermatologic diseases: 4. Allergic states: 5. Ophthalmic diseases: 6. Respiratory diseases: 7. Edematous states: 8. Nervous system: As adjunctive therapy for short-term administration (to tide the patient over an acute episode or exacerbation) in:Psoriatic arthritis.Rheumatoid arthritis, including juvenile rheumatoid arthritis (selected cases may require low-dose maintenance ther

Labeler: ANI Pharmaceuticals, Inc.Updated: 2026-02-09T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Purified Cortrophin Gel is contraindicated for intravenous administration. Purified Cortrophin Gel is contraindicated in patients with scleroderma, osteoporosis, systemic fungal infections, ocular herpes simplex, recent surgery, history of or the presence of a peptic ulcer, congestive heart failure,

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

13 trials linked to this intervention

13
Total Trials
3
Recruiting
6
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Corticotherapy versus adrenocorticotropic hormone for treating West syndrome: a systematic review and meta-analysis.
Farias Elizabeth Honorato de, Silva Anderson Matheus Pereira da, Santos Karlos Daniell Araújo Dos et al. · Arq Neuropsiquiatr · 2025
PMID: 40886708Meta-AnalysisFull text (PMC)
Adrenocorticotropic Hormone versus Prednisolone for Infantile Epileptic Spasms Syndrome: A Systematic Review and Economic Evaluation.
Gao Ruonan, Cheng Xiao, Huang Liang et al. · Neuropediatrics · 2025
PMID: 39900086Meta-Analysis
Immune checkpoint inhibitor-induced isolated adrenocorticotropic hormone deficiency: a systematic review.
Wang Fen, Shi Xiaoli, Yu Xuefeng et al. · Front Endocrinol (Lausanne) · 2024
PMID: 38318292Meta-AnalysisFull text (PMC)
Idiopathic isolated adrenocorticotropic hormone deficiency: a systematic review of a heterogeneous and underreported disease.
Van Mieghem E, De Block C, De Herdt C · Pituitary · 2024
PMID: 38151529Meta-Analysis
Adrenocorticotropic Hormone-Producing Pancreatic Neuroendocrine Neoplasms: A Systematic Review.
Wu Yi, Xiong Guangbing, Zhang Hang et al. · Endocr Pract · 2021
PMID: 33616046Meta-Analysis
Adrenal venous sampling with adrenocorticotropic hormone stimulation: A meta-analysis.
Yang Junfeng, Yu Yanhong, Zhang Zhuorui et al. · Int J Clin Pract · 2021
PMID: 34096147Meta-Analysis
Cost-effectiveness of adrenocorticotropic hormone versus oral steroids for infantile spasms.
Sánchez Fernández Iván, Amengual-Gual Marta, Gaínza-Lein Marina et al. · Epilepsia · 2021
PMID: 33417252Meta-Analysis
Prednisolone/prednisone as adrenocorticotropic hormone alternative for infantile spasms: a meta-analysis of randomized controlled trials.
Li Shaojun, Zhong Xuefei, Hong Siqi et al. · Dev Med Child Neurol · 2020
PMID: 31903560Meta-Analysis
Effectiveness of corticosteroids versus adrenocorticotropic hormone for infantile spasms: a systematic review and meta-analysis.
Chang Yin-Hsi, Chen Chiehfeng, Chen Shu-Huey et al. · Ann Clin Transl Neurol · 2019
PMID: 31657133Meta-AnalysisFull text (PMC)
[Effect of prednisolone and adrenocorticotropic hormone in the treatment of infantile spasms: a Meta analysis].
Luo Ke-Ren, Tang Jun, Mu De-Zhi · Zhongguo Dang Dai Er Ke Za Zhi · 2019
PMID: 31315764Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Adrenocorticotropic hormone (substance)
SNOMED CT
40789008
UMLS CUI
C0001655
RxNorm CUI
376
Labeler
ANI Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 16 entities in the Healos knowledge graph.

11
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
13
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.