Substance / Medication

Aflibercept

Overview

Active Ingredient
aflibercept
RxNorm CUI
1232150

Indications

EYLEA is indicated for the treatment of:

Labeler: Regeneron Pharmaceuticals, Inc.Updated: 2025-12-18T00:00:00.000ZFull label on DailyMed

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

60 trials linked to this intervention

60
Total Trials
4
Recruiting
21
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and safety of dexamethasone versus intravitreal aflibercept implants for macular edema: a systematic review and meta-analysis.
Moghib Khaled, Shivashankar Trisha, Abunamoos Abdallah et al. · Eur J Med Res · 2025
PMID: 40229845Meta-AnalysisFull text (PMC)
Comparative outcomes of aflibercept biosimilars and reference aflibercept in nAMD: a systematic review and meta-analysis.
Sawires Korolos, Nithianandan Harrish, Somani Sohel · BMJ Open Ophthalmol · 2025
PMID: 41177553Meta-AnalysisFull text (PMC)
Aflibercept versus ranibizumab for diabetic macular edema: A meta-analysis.
Chen Haiyan, Shi Xuehui, Zhang Wang et al. · Eur J Ophthalmol · 2024
PMID: 37226427Meta-AnalysisFull text (PMC)
Aflibercept for long-term treatment of diabetic macular edema and proliferative diabetic retinopathy: a meta-analysis.
Xie Xiao, Lian Chao, Zhang Zhiping et al. · Front Endocrinol (Lausanne) · 2023
PMID: 37260449Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Aflibercept (substance)
SNOMED CT
703840003
UMLS CUI
C1134659
RxNorm CUI
1232150
Labeler
Regeneron Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
60
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.