Substance / Medication

Alpha-1-protease inhibitor

Overview

Active Ingredient
alpha 1-antitrypsin
RxNorm CUI
535

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Alpha-1 antitrypsin deficiency and granulomatosis with polyangiitis: a systematic review and meta-analysis.
Alluhibi Reem, Baradwaaj Shashank, Heyer-Chauhan Nina et al. · Eur Respir Rev · 2025
PMID: 41125409Meta-AnalysisFull text (PMC)
Rare variants in alpha 1 antitrypsin deficiency: a systematic literature review.
Ferrarotti Ilaria, Wencker Marion, Chorostowska-Wynimko Joanna · Orphanet J Rare Dis · 2024
PMID: 38388492Meta-AnalysisFull text (PMC)
Meta-analysis: Prevalence of significant or advanced fibrosis in adults with alpha-1-antitrypsin deficiency.
Huang Daniel Q, Chan Kai En, Tan Caitlyn et al. · Aliment Pharmacol Ther · 2023
PMID: 37089038Meta-AnalysisFull text (PMC)
Disease burden associated with alpha-1 antitrypsin deficiency: systematic and structured literature reviews.
Miravitlles Marc, Herepath Mike, Priyendu Asim et al. · Eur Respir Rev · 2022
PMID: 35321931Meta-AnalysisFull text (PMC)
Prevalence of α-antitrypsin PiZZ genotypes in patients with COPD in Europe: a systematic review.
Blanco Ignacio, Diego Isidro, Bueno Patricia et al. · Eur Respir Rev · 2020
PMID: 32699024Meta-AnalysisFull text (PMC)
Preparation and properties of an alpha-1-protease inhibitor concentrate with high specific activity.
Mattes E, Matthiessen H P, Turecek P L et al. · Vox Sang · 2001
PMID: 11520413Observational
Treatment of panniculitis associated with alpha-1-antitrypsin deficiency with alpha-1-protease inhibitor.
Kjus Trine, Lützow-Holm Claus, Christensen Ole B · Acta Derm Venereol · 2003
PMID: 14690345Case Report

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Human alpha1 proteinase inhibitor (substance)
SNOMED CT
14767006
UMLS CUI
C0795657
RxNorm CUI
535

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.