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Substance / Medication

Amikacin sulfate

SNOMED 1269009UMLS C0002501

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Staphylococcal infectious disease
Endocarditis
Postoperative wound infection
Pseudomonas infection
Urinary tract infectious disease
Colibacillosis
Bacterial infection caused by Serratia
Bacterial infectious disease
Mycobacteriosis
Systemic infection
Soft tissue infection
Infection of skin
Burn
Infectious disease of abdomen
Infectious disease of central nervous system
Proteus infection
Respiratory tract infection
Surgical site infection
Infection caused by Klebsiella
Acinetobacter infection

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

99 trials linked to this intervention

99
Total Trials
26
Recruiting
8
With Results

Recent Trials

The Study of Drotrecogin Alfa (Activated) in a Subpopulation of Adult Patients With Severe Sepsis

NCT00045760Phase 4Completed

A Trial of Heparin in Patients With Severe Sepsis Who Are Undergoing Treatment With Drotrecogin Alfa (Activated)

NCT00049777Phase 4Completed2000 enrolled

A Safety Evaluation of Drotrecogin Alfa (Activated) in Patients With Blood Cancer, Severe Infection Related to Bone Marrow Transplantation

NCT00067730Phase 4Completed7 enrolled

Leukocyte Depletion of Autologous Whole Blood

NCT00176124Phase 4Completed1089 enrolled

Study of the Use of Coated Venous Catheters in the Critically Ill Child

NCT00202813Phase 4Completed500 enrolled
View all 99 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Prevention of renal stone disease recurrence. A systematic review of contemporary pharmaceutical options.
Sfoungaristos Stavros, Gofrit Ofer N, Yutkin Vladimir et al. · Expert Opin Pharmacother · 2015
PMID: 25881654Meta-Analysis
Effect of Dose on Intra-Articular Amikacin Sulfate Concentrations Following Intravenous Regional Limb Perfusion in Horses.
Harvey Alison, Kilcoyne Isabelle, Byrne Barbara A et al. · Vet Surg · 2016
PMID: 27684571RCT
Effects of regional limb perfusion volume on concentrations of amikacin sulfate in synovial and interstitial fluid samples from anesthetized horses.
Godfrey Jennifer L, Hardy Joanne, Cohen Noah D · Am J Vet Res · 2016
PMID: 27227495RCT
Strategy to control catheter encrustation with citrated drinks: a randomized crossover study.
Khan Azhar, Housami Fadi, Melotti Roberto et al. · J Urol · 2010
PMID: 20171661RCT
In vitro and in vivo evaluation of ferric-hyaluronate implants for delivery of amikacin sulfate to the tarsocrural joint of horses.
Cribb Nicola C, Bouré Ludovic P, Hanna W J Brad et al. · Vet Surg · 2009
PMID: 19538672RCT
Effect of topical application of 1% diclofenac sodium liposomal cream on inflammation in healthy horses undergoing intravenous regional limb perfusion with amikacin sulfate.
Levine David G, Epstein Kira L, Neelis Dana A et al. · Am J Vet Res · 2009
PMID: 19878013RCT
From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis.
Norsworthy Allison N, Pearson Melanie M · Trends Microbiol · 2017
PMID: 28017513ReviewFull text (PMC)
The Effects of Mepivacaine Hydrochloride on Antimicrobial Activity and Mechanical Nociceptive Threshold During Amikacin Sulfate Regional Limb Perfusion in the Horse.
Colbath Aimée C, Wittenburg Luke A, Gold Jenifer R et al. · Vet Surg · 2016
PMID: 27416788Trial
Pharmacokinetics of a combination of amikacin sulfate and penicillin G sodium for intravenous regional limb perfusion in adult horses.
Nieto Jorge E, Trela Jan, Stanley Scott D et al. · Can J Vet Res · 2016
PMID: 27408337TrialFull text (PMC)
Accumulation of amikacin in synovial fluid after regional limb perfusion of amikacin sulfate alone and in combination with ticarcillin/clavulanate in horses.
Zantingh Alanna J, Schwark Wayne S, Fubini Susan L et al. · Vet Surg · 2014
PMID: 24467593Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Amikacin sulfate (substance)
SNOMED CT
1269009
UMLS CUI
C0002501

Clinical Data

This intervention maps to 20 entities in the Ltrl knowledge graph.

20
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
99
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.