Substance / Medication

Amitriptyline

Overview

Active Ingredient
amitriptyline
RxNorm CUI
704

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

14 trials linked to this intervention

14
Total Trials
2
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Does amitriptyline help for irritable bowel syndrome pain management?: An updated systematic review and meta-analysis.
Alhajaji Raghad, Alfahmi Manal, Alshareef Eatedal Mohammed et al. · Medicine (Baltimore) · 2026
PMID: 41496023Meta-AnalysisFull text (PMC)
Efficacy of Amitriptyline in Irritable Bowel Syndrome: A Systematic Review and Meta-analysis.
Iqbal Minahil, Hira Sara, Saeed Humza et al. · J Neurogastroenterol Motil · 2025
PMID: 39779201Meta-AnalysisFull text (PMC)
Amitriptyline's anticholinergic adverse drug reactions-A systematic multiple-indication review and meta-analysis.
Brueckle Maria-Sophie, Thomas Elizabeth T, Seide Svenja Elisabeth et al. · PLoS One · 2023
PMID: 37018325Meta-AnalysisFull text (PMC)
European Headache Federation (EHF) critical re-appraisal and meta-analysis of oral drugs in migraine prevention-part 1: amitriptyline.
Lampl Christian, Versijpt Jan, Amin Faisal Mohammad et al. · J Headache Pain · 2023
PMID: 37038134Meta-AnalysisFull text (PMC)
Amitriptyline and Sexual Function: A Systematic Review Updated for Sexual Health Practice.
Chen Louis Wei-Hsi, Chen Melody Yun-Si, Lian Zhi-Ping et al. · Am J Mens Health · 2018
PMID: 29019272Meta-AnalysisFull text (PMC)
Amitriptyline for musculoskeletal complaints: a systematic review.
van den Driest Jacoline J, Bierma-Zeinstra Sita M A, Bindels Patrick J E et al. · Fam Pract · 2017
PMID: 28334783Meta-Analysis
Amitriptyline for neuropathic pain in adults.
Moore R Andrew, Derry Sheena, Aldington Dominic et al. · Cochrane Database Syst Rev · 2015
PMID: 26146793Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Amitriptyline (substance)
SNOMED CT
372726002
UMLS CUI
C0002600
RxNorm CUI
704

Clinical Data

This intervention maps to 8 entities in the Healos knowledge graph.

2
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
14
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.