Substance / Medication

Apremilast

Overview

Active Ingredient
apremilast
RxNorm CUI
1492727
Labeler: Amgen, IncUpdated: 2025-12-23T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Warnings and Precautions (5.1) Adverse Reactions (6.1) [see, see] OTEZLA/OTEZLA XR is contraindicated in patients with a known hypersensitivity to apremilast or to any of the excipients in the formulation.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

18 trials linked to this intervention

18
Total Trials
0
Recruiting
14
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Small molecules in idiopathic inflammatory myopathies: a systematic review and a multicenter case series about Janus kinase inhibitors and apremilast.
Rizzo Chiara, Grazzini Silvia, Conticini Edoardo et al. · Reumatismo · 2025
PMID: 39810571Meta-Analysis
Safety and Immunogenicity of Live Attenuated Vaccine Administration in Patients Undergoing Treatment With Dupilumab and Apremilast: A Systematic Review.
Larney Conor, Foley Peter, Daniel Benjamin S · Australas J Dermatol · 2025
PMID: 40125904Meta-Analysis
Efficacy and safety of apremilast monotherapy in moderate-to-severe plaque psoriasis: A systematic review and meta-analysis.
Aljefri Yara E, Ghaddaf Abdullah A, Alkhunani Tala A et al. · Dermatol Ther · 2022
PMID: 35499185Meta-Analysis
Beneficial effects of apremilast on genital ulcers, skin lesions, and arthritis in patients with Behçet's disease: A systematic review and meta-analysis.
Iizuka Yuki, Takase-Minegishi Kaoru, Hirahara Lisa et al. · Mod Rheumatol · 2022
PMID: 34752620Meta-Analysis
Combination Therapy with Apremilast and Biologics for Psoriasis: A Systematic Review.
Gyldenløve Mette, Alinaghi Farzad, Zachariae Claus et al. · Am J Clin Dermatol · 2022
PMID: 35737251Meta-Analysis
On- and Off-Label Uses of Apremilast in Dermatology.
Plachouri Kerasia-Maria, Georgiou Sophia · Acta Dermatovenerol Croat · 2020
PMID: 33422172Meta-Analysis
Secukinumab for psoriatic arthritis: comparative effectiveness versus licensed biologics/apremilast: a network meta-analysis.
McInnes Iain B, Nash Peter, Ritchlin Christopher et al. · J Comp Eff Res · 2018
PMID: 30230361Meta-Analysis
A meta-analysis of apremilast on psoriatic arthritis long-term assessment of clinical efficacy (PALACE).
Qu Xiaoyu, Zhang Sixi, Tao Lina et al. · Expert Rev Clin Pharmacol · 2016
PMID: 26918950Meta-Analysis
Apremilast Versus Placebo for Genital Erosive Lichen Planus in Women: A Randomized Controlled Trial.
Skullerud Kristin Helene, Gjersvik Petter, Pripp Are Hugo et al. · J Low Genit Tract Dis · 2026
PMID: 41085970RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Apremilast (substance)
SNOMED CT
703350008
UMLS CUI
C1678805
RxNorm CUI
1492727
Labeler
Amgen, Inc

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
18
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.