Substance / Medication

Arginine

Overview

Active Ingredient
arginine
RxNorm CUI
1091

Indications

Aminosyn II, Sulfite-Free, (an amino acid injection) infused with dextrose by peripheral vein infusion is indicated as a source of nitrogen in the nutritional support of patients with adequate stores of body fat, in whom, for short periods of time, oral nutrition cannot be tolerated, is undesirable, or inadequate. SUPPLEMENTAL ELECTROLYTES, IN ACCORDANCE WITH THE PRESCRIPTION OF THE ATTENDING PHYSICIAN, MUST BE ADDED TO AMINOSYN II SOLUTIONS WITHOUT ELECTROLYTES. Aminosyn II can be administered

Labeler: ICU Medical Inc.Updated: 2025-11-02T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

Pharmacy Bulk Package – Not For Direct Infusion.

Contraindications

When this intervention should not be used

This preparation should not be used in patients with hepatic coma or metabolic disorders involving impaired nitrogen utilization.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

8 trials linked to this intervention

8
Total Trials
2
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Methylarginine levels and their impact on vascular aging: a systematic review.
Almeida do Carmo Eduardo Eric, Diogo Ferreira Celia Cristina, Silva de Andrade Roberta Melquiades · Vasc Biol · 2025
PMID: 41378901Meta-AnalysisFull text (PMC)
L-Arginine and L-Citrulline for Prevention and Treatment of Pre-Eclampsia: A Systematic Review and Meta-Analysis.
Makama Maureen, McDougall Annie R A, Cao Jenny et al. · BJOG · 2025
PMID: 39800868Meta-AnalysisFull text (PMC)
l-Arginine supplementation for pregnant and lactating sows may improve the performance of piglets: A systematic review.
Cruz Fábio Loures, Mendes Melissa Fabíola Dos Santos Alves, Silva Thais Oliveira et al. · J Anim Physiol Anim Nutr (Berl) · 2025
PMID: 39152530Meta-Analysis
Efficacy of L-Arginine for Preventing Preeclampsia and Improving Maternal and Neonatal Outcomes in High-Risk Pregnancies: A Systematic Review and Meta-Analysis.
Naderipour Fatemeh, Keshavarzi Fariba, Mirfakhraee Hosna et al. · Int J Fertil Steril · 2024
PMID: 39564822Meta-AnalysisFull text (PMC)
Arginine on immune function and post-operative obstructions in colorectal cancer patients: a meta-analysis.
Ouyang Zan, Chen Ping, Zhang Min et al. · BMC Cancer · 2024
PMID: 39223466Meta-AnalysisFull text (PMC)
A systematic review and meta-analysis of nitric oxide-associated arginine metabolites in schizophrenia.
Zinellu Angelo, Tommasi Sara, Carru Ciriaco et al. · Transl Psychiatry · 2024
PMID: 39414767Meta-AnalysisFull text (PMC)
L-Arginine supplementation in pregnancy: a systematic review of maternal and fetal outcomes.
Menichini Daniela, Feliciello Lia, Neri Isabella et al. · J Matern Fetal Neonatal Med · 2023
PMID: 37258415Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Arginine (substance)
SNOMED CT
52625008
UMLS CUI
C0003765
RxNorm CUI
1091
Labeler
ICU Medical Inc.

Clinical Data

This intervention maps to 3 entities in the Healos knowledge graph.

2
Conditions
1
Biomarkers
0
Specialists
0
Symptoms
8
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.