Substance / Medication

Baclofen

Overview

Active Ingredient
baclofen
RxNorm CUI
1292

Indications

Baclofen tablets USP are useful for the alleviation of signs and symptoms of spasticity resulting from multiple sclerosis, particularly for the relief of flexor spasms and concomitant pain, clonus, and muscular rigidity. Patients should have reversible spasticity so that baclofen treatment will aid in restoring residual function. Baclofen tablets USP may also be of some value in patients with spinal cord injuries and other spinal cord diseases. Baclofen tablets USP are not indicated in the treat

Labeler: A-S Medication SolutionsUpdated: 2026-02-24T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Hypersensitivity to baclofen.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

4 trials linked to this intervention

4
Total Trials
3
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Clinical Presentations and Treatment of Baclofen Toxicity and Withdrawal: A Systematic Review.
Iqbal Minahil, Modi Parth, Sehgal Kush et al. · CNS Drugs · 2026
PMID: 41555041Meta-Analysis
Optimal Dose of Baclofen for the Treatment of Alcohol Use Disorder: A Systematic Review and Dose-Response Meta-analysis.
Kotake Kazumasa, So Ryuhei, Hashimoto Nozomu et al. · CNS Drugs · 2025
PMID: 40347309Meta-Analysis
Efficacy of Baclofen as Add-on Therapy for Refractory Gastroesophageal Reflux Disease: A Meta-analysis.
Dong Hongyi, Luo Ying, Liu Diangang et al. · J Clin Gastroenterol · 2025
PMID: 38869961Meta-AnalysisFull text (PMC)
Baclofen and Tizanidine Adverse Effects Observed Among Community-Dwelling Adults Above the Age of 50 Years: A Systematic Review.
Killam-Worrall Lisa, Brand Romana, Castro Janine R et al. · Ann Pharmacother · 2024
PMID: 37589096Meta-Analysis
Publication Trends of Research on Intrathecal Baclofen Therapy: A Bibliometric Analysis of the Literature.
Rech Matheus Machado, Ramos Miguel Bertelli, Piva Felipe Eduardo et al. · World Neurosurg · 2024
PMID: 37567560Meta-Analysis
Intrathecal baclofen for the management of hereditary spastic paraparesis: a systematic review.
Viana Pinto Luisa, Romeiro Isabel, Gouveia Filipa et al. · Int J Rehabil Res · 2024
PMID: 38251093Meta-Analysis
Outcomes, complications, and dosing of intrathecal baclofen in the treatment of multiple sclerosis: a systematic review.
Cozzi Francesca M, Zuckerman David, Sacknovitz Ariel et al. · Neurosurg Focus · 2024
PMID: 38823049Meta-Analysis
Baclofen for alcohol use disorder.
Agabio Roberta, Saulle Rosella, Rösner Susanne et al. · Cochrane Database Syst Rev · 2023
PMID: 36637087Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Baclofen (substance)
SNOMED CT
387342009
UMLS CUI
C0004609
RxNorm CUI
1292
Labeler
A-S Medication Solutions

Clinical Data

This intervention maps to 14 entities in the Healos knowledge graph.

9
Conditions
3
Biomarkers
1
Specialists
0
Symptoms
4
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.