Substance / Medication

Belumosudil

Overview

Active Ingredient
belumosudil
RxNorm CUI
2564025

Indications

REZUROCK is indicated for the treatment of adult and pediatric patients 12 years and older with chronic graft-versus-host disease (chronic GVHD) after failure of at least two prior lines of systemic therapy.

Labeler: Kadmon Pharmaceuticals, LLCUpdated: 2026-02-03T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Organ Responses, Survival, and Safety of Belumosudil in Chronic Graft-Versus-Host Disease: A Systematic Review and Meta-Analysis.
Gadelmawla Ahmed Farid, Alsaied Mohamed A, Alkuwaiti Mohanad A et al. · Clin Transplant · 2026
PMID: 41556727Meta-Analysis
Unraveling the rationale and conducting a comprehensive assessment of KD025 (Belumosudil) as a candidate drug for inhibiting adipogenic differentiation-a systematic review.
Barbalho Sandra Maria, de Alvares Goulart Ricardo, Minniti Giulia et al. · Naunyn Schmiedebergs Arch Pharmacol · 2024
PMID: 37966572Meta-Analysis
Belumosudil in diffuse cutaneous systemic sclerosis: a randomized, double-blind, open-label extension, placebo-controlled, phase 2 study.
Chung Lorinda, Silver Richard M, Steen Virginia et al. · Rheumatology (Oxford) · 2025
PMID: 40088930RCTFull text (PMC)
Belumosudil for Chronic Graft-Versus-Host Disease: Analysis of Long-Term Results from the KD025-208 and ROCKstar Studies.
Lee Stephanie J, Pavletic Steven, Blazar Bruce R et al. · Transplant Cell Ther · 2025
PMID: 40318736TrialFull text (PMC)
Pharmacokinetics of Belumosudil and Its Metabolites in Individuals With Hepatic Impairment.
Schueller Olivier, Esposito Virginie, Lohmer Lauren et al. · Clin Transl Sci · 2025
PMID: 40614122TrialFull text (PMC)
A Phase 1 Thorough QT/QTc Study of Therapeutic and Supratherapeutic Doses of Belumosudil in Healthy Subjects.
Schueller Olivier, Lohmer Lauren, Xue Hongqi et al. · Clin Pharmacol Drug Dev · 2022
PMID: 35881051Trial
Phase 1 Studies to Evaluate the Food Effect and Relative Bioavailability of Tablet and Capsule Formulations of Belumosudil in Healthy Adult Subjects.
Schueller Olivier, McDermott John, Evans Phil et al. · Clin Pharmacol Drug Dev · 2022
PMID: 35238174Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Belumosudil (substance)
SNOMED CT
1163566003
UMLS CUI
C5418179
RxNorm CUI
2564025
Labeler
Kadmon Pharmaceuticals, LLC

Clinical Data

This intervention maps to 1 entities in the Ltrl knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.