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Substance / Medication

Bethanechol

SNOMED 372698003UMLS C0053526

Overview

Active Ingredient
bethanechol
RxNorm CUI
19257

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Gastroesophageal reflux disease
Retention of urine

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

4 trials linked to this intervention

4
Total Trials
1
Recruiting
2
With Results

Recent Trials

Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery

NCT03287089Phase 4Completed164 enrolled

Assessing Pyridium for Post-Sling Urinary Retention

NCT03302936Phase 4Completed98 enrolled

Prevention of Postoperative Urinary Retention With Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty

NCT03808155Phase 4Completed170 enrolled

Evaluation of the Efficacy of the Addition of Magnesium Sulfate to Morphine on the Occurrence of Acute Urinary Retention Following Epidural Anesthesia for Cesarean Section.

NCT06442995Phase 4Recruiting290 enrolled
View all 4 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy of bethanechol chloride in the treatment of radiation-induced xerostomia in patients with head and neck cancer: A systematic review and meta-analysis.
Moral Nakamura Denise, da Graça Pinto Henrique, Baena Elchin Cintia et al. · Radiother Oncol · 2023
PMID: 37207874Meta-Analysis
Bethanechol used to prevent salivary gland dysfunction in patients submitted to radioactive iodine therapy: A double blind, placebo-controlled, randomized study.
Campanhã Daniel, PereiraLIMA Eduardo Nóbrega, Alves Fábio Abreu et al. · J Stomatol Oral Maxillofac Surg · 2022
PMID: 34954424RCT
Bethanechol chloride for the prevention of bladder dysfunction after radical hysterectomy in gynecologic cancer patients: a randomized controlled trial study.
Manchana Tarinee, Prasartsakulchai Chalisa · Int J Gynecol Cancer · 2011
PMID: 21546875RCT
The effect of oral buspirone, pyridostigmine, and bethanechol on esophageal function evaluated with combined multichannel esophageal impedance-manometry in healthy volunteers.
Blonski Wojciech, Vela Marcelo F, Freeman Janice et al. · J Clin Gastroenterol · 2009
PMID: 18987553RCT
A phase 0, window of opportunity study of parasympathetic stimulation with bethanechol in localized pancreatic adenocarcinoma prior to surgery.
White Ruth A, Mezzano-Robinson Valeria, Shi Qiongyu et al. · Oncologist · 2025
PMID: 40448309TrialFull text (PMC)
Double blind randomized prospective trial of bethanechol in the prevention of radiation-induced salivary gland dysfunction in head and neck cancer patients.
Jaguar Graziella Chagas, Lima Eduardo Nóbrega Pereira, Kowalski Luiz Paulo et al. · Radiother Oncol · 2015
PMID: 25890572Trial
Topical bethanechol for the improvement of esophageal dysmotility: a pilot study.
O'Rourke Ashli, Weinberger Paul, Morrison Michele et al. · Ann Otol Rhinol Laryngol · 2013
PMID: 24027856Trial
A randomized phase III prospective trial of bethanechol to prevent mucositis, candidiasis, and taste loss in patients with head and neck cancer undergoing radiotherapy: a secondary analysis.
Jham Bruno C, Chen Haiyan, Carvalho Andre L et al. · J Oral Sci · 2009
PMID: 20032609Trial
A randomized phase III prospective trial of bethanechol to prevent radiotherapy-induced salivary gland damage in patients with head and neck cancer.
Jham Bruno Correia, Teixeira Inah Vanetti, Aboud Clarissa Gonçalves et al. · Oral Oncol · 2007
PMID: 16798061Trial
Prostaglandin E2 and bethanechol in combination for treating detrusor underactivity.
Hindley R G, Brierly R D, Thomas P J · BJU Int · 2004
PMID: 14678375Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Bethanechol (substance)
SNOMED CT
372698003
UMLS CUI
C0053526
RxNorm CUI
19257

Clinical Data

This intervention maps to 2 entities in the Ltrl knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
4
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.