Substance / Medication

Bicalutamide

Overview

Active Ingredient
bicalutamide
RxNorm CUI
83008

Indications

Bicalutamide tablets 50 mg daily is indicated 2 for use in combination therapy with a luteinizing hormone-releasing hormone (LHRH) analog for the treatment of Stage Dmetastatic carcinoma of the prostate. Bicalutamide tablets 150 mg daily is not approved Clinical Studies (14.2) [see]. for use alone or with other treatments

Labeler: Golden State Medical Supply, Inc.Updated: 2025-12-10T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Bicalutamide tablets are contraindicated in: Bicalutamide tablets are contraindicated in any patient who has shown a hypersensitivity reaction to the drug or any of the tablet’s components. Hypersensitivity reactions including angioneurotic edema and urticaria have been reported. Bicalutamide tablet

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Prevention of bicalutamide-induced breast events in patients with prostate cancer: a meta-analysis of randomized controlled trials.
Spagnolo Luca, Tienforti Daniele, Moretto Carolina et al. · J Endocrinol Invest · 2025
PMID: 40244528Meta-AnalysisFull text (PMC)
GnRH antagonist monotherapy versus a GnRH agonist plus bicalutamide for advanced hormone-sensitive prostate cancer; KYUCOG-1401.
Yokomizo Akira, Shiota Masaki, Morokuma Futoshi et al. · Int J Urol · 2024
PMID: 38148124RCT
Enzalutamide versus bicalutamide in patients with nonmetastatic castration-resistant prostate cancer: a prespecified subgroup analysis of the STRIVE trial.
Penson David F, Armstrong Andrew J, Concepcion Raoul S et al. · Prostate Cancer Prostatic Dis · 2022
PMID: 34621011RCTFull text (PMC)
Goserelin and bicalutamide treatments alter the expression of microRNAs in the prostate.
Lehmusvaara Saara, Erkkilä Timo, Urbanucci Alfonso et al. · Prostate · 2013
PMID: 22674191RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Bicalutamide (substance)
SNOMED CT
386908000
UMLS CUI
C0285590
RxNorm CUI
83008
Labeler
Golden State Medical Supply, Inc.

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.