Substance / Medication

Bretylium

Overview

Active Ingredient
bretylium
RxNorm CUI
19685

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

12 trials linked to this intervention

12
Total Trials
1
Recruiting
4
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Amiodarone and bretylium in the treatment of hypothermic ventricular fibrillation in a canine model.
Stoner Jason, Martin Gerard, O'Mara Kevin et al. · Acad Emerg Med · 2003
PMID: 12615580Observational
Bretylium or 6-OHDA-resistant, action potential-evoked Ca2+ transients in varicosities of the mouse vas deferens.
Jackson V Margaret, Cunnane Tom C · Br J Pharmacol · 2002
PMID: 11959786ObservationalFull text (PMC)
Refractory Electrical Storm suppression by bretylium.
Kapoor John R, Batsford William P, Foody JoAnne M · Int J Cardiol · 2006
PMID: 16904769Case Report
Localized abdominal pain following sympathetic blockade with bretylium for the management of complex regional pain syndrome.
Molyneux M, Venn R, O'Dwyer J · Eur J Anaesthesiol · 2002
PMID: 11999600Case Report
Bretylium, a Class III Antiarrhythmic, Returns to the Market.
Thind Munveer, Sullivan Renee M, Williams Richard N et al. · Am J Cardiol · 2020
PMID: 32843146Other
The Bretylium Saga: A Novel "Old Drug" for Cardiac Resuscitation.
Bacaner Marvin, Somberg John · Am J Cardiol · 2020
PMID: 32238277Preclinical
Inhibition of the Na,K-ATPase by the antiarrhythmic drug, Bretylium.
Gatto Craig, Barkulis C Theodore, Schneider William R et al. · Ann N Y Acad Sci · 2003
PMID: 12763901Preclinical

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Bretylium (substance)
SNOMED CT
372774002
UMLS CUI
C0054040
RxNorm CUI
19685

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
12
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.