Substance / Medication

Captopril

Overview

Active Ingredient
captopril
RxNorm CUI
1998

Indications

Hypertension: Captopril tablets, USP, are indicated for the treatment of hypertension. WARNINGS In using captopril tablets, USP, consideration should be given to the risk of neutropenia/agranulocytosis (see). Captopril tablets, USP may be used as initial therapy for patients with normal renal function, in whom the risk is relatively low. In patients with impaired renal function, particularly those with collagen vascular disease, captopril should be reserved for hypertensives who have either deve

Labeler: Major PharmaceuticalsUpdated: 2026-01-23T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

• When pregnancy is detected, discontinue captopril tablets as soon as possible. • Fetal Toxicity Drugs that act directly on the renin-angiotensin system can cause injury and death to the developing fetus. See WARNINGS:

Contraindications

When this intervention should not be used

Captopril is contraindicated in patients who are hypersensitive to this product or any other angiotensin-converting enzyme inhibitor (e.g., a patient who has experienced angioedema during therapy with any other ACE inhibitor). PRECAUTIONS Drug Interactions , Do not co-administer aliskiren with capto

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

3 trials linked to this intervention

3
Total Trials
1
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
[The ACE inhibitor, captopril, in the light of new clinical studies].
Simko F, Simková M, Kovacs L · Ceska Slov Farm · 2002
PMID: 11928278Meta-Analysis
Effects of Adding Pentoxifylline to Captopril on Primary Hypertension: A Pilot Randomized Clinical Trial.
Namdar Hossein, Khani Elnaz, Pourrashid Mohammad Hassan et al. · J Clin Pharmacol · 2020
PMID: 31489650RCT
Clonidine versus Captopril for Severe Postpartum Hypertension: A Randomized Controlled Trial.
Noronha Neto C Carlos, Maia Sabina S B, Katz Leila et al. · PLoS One · 2017
PMID: 28125624RCTFull text (PMC)
Captopril does not Potentiate Post-Exercise Hypotension: A Randomized Crossover Study.
Queiroz Andréia Cristiane Carrenho, Sousa Julio Cesar Silva, Silva Natan Daniel et al. · Int J Sports Med · 2017
PMID: 28219104RCT
Systolic and diastolic component of orthostatic hypotension and cardiovascular events in hypertensive patients: the Captopril Prevention Project.
Fedorowski Artur, Wahlstrand Björn, Hedner Thomas et al. · J Hypertens · 2014
PMID: 24061546RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Captopril (substance)
SNOMED CT
387160004
UMLS CUI
C0006938
RxNorm CUI
1998
Labeler
Major Pharmaceuticals

Clinical Data

This intervention maps to 17 entities in the Healos knowledge graph.

6
Conditions
5
Biomarkers
3
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.