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Substance / Medication

Carbamide peroxide

SNOMED 90581007 UMLS C0108342

Overview

Active Ingredient

carbamide peroxide

RxNorm CUI

47686

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Mucous membrane inflammation

Hearing disorder

Bullous ichthyosiform erythroderma

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

LOINC 1903-4

secondary

C reactive protein

LOINC 1988-5

secondary

Calcidiol+ercalcidiol

LOINC 14635-7

secondary

LOINC 2345-7

secondary

Clinical Trials

108 trials linked to this intervention

108

Total Trials

14

Recruiting

14

With Results

Recent Trials

Genetic Analysis of Hereditary Disorders of Hearing and Balance

NCT00023049Completed335 enrolled

Mouth Care Regimes During Radiotherapy

NCT00138827Phase 4Completed50 enrolled

Subcutaneous Amifostine Safety Study

NCT00158041Phase 4Completed452 enrolled

Study of Scaling and Root Planing (SRP) With PerioWave vs. SRP Alone in Chronic Periodontitis

NCT00297518Phase 4Completed40 enrolled

Topical Morphine for Stomatitis-related Pain Induced by Chemotherapy

NCT00357942Phase 4Completed72 enrolled

View all 108 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Using violet light during in-office tooth bleaching to enhance the efficacy of carbamide peroxide without increasing bleaching sensitivity: a systematic review and meta-analysis.

Bessa Mariana Silva de, Santos Kaiza de Sousa, Boa Patrick Wesley Marques de et al. · Lasers Med Sci · 2025

PMID: 40346438Meta-Analysis

Does the addition of potassium nitrate to carbamide peroxide gel reduce sensitivity during at-home bleaching?

Costacurta A O, Kunz Pvm, Silva R C et al. · Aust Dent J · 2020

PMID: 31765021Meta-Analysis

Effect of bleaching with carbamide peroxide on shear bond strength of orthodontic brackets: A meta-analysis of in vitro studies.

Azizi Fatemeh, Bahrami Kiana, Imani Mohammad Moslem et al. · Int Orthod · 2020

PMID: 32241631Meta-Analysis

In-Office Dental Bleaching Using 37% Carbamide Peroxide Versus 35% Hydrogen Peroxide: A Randomized, Double-Blind Clinical Trial.

da Silva Karine Letícia, Crovador Cleysson, Stanislawczuk Rodrigo et al. · J Esthet Restor Dent · 2025

PMID: 39288017RCT

Different daily times for at-home bleaching with 10% carbamide peroxide: A randomized single-blind, noninferiority controlled trial.

Terra Renata Maria Oleniki, Sutil Elisama, Ferreira Cordeiro Deisy Cristina et al. · J Am Dent Assoc · 2025

PMID: 39779067RCT

Effect of carbamide peroxide on biomechanical properties of vacuum-formed retainers: A split-mouth randomized controlled trial.

Jin Carrol, Gray Andrew R, Brunton Paul A et al. · J Dent · 2024

PMID: 38432352RCT

Chemical behavior of 20%-22% carbamide peroxide gels in at-home bleaching: Randomized crossover in situ trial.

Mailart Mariane Cintra, Dos Santos Karine Carvalho, Torres Carlos Rocha Gomes et al. · J Esthet Restor Dent · 2023

PMID: 36200919RCT

Effectiveness and adverse effects of at-home dental bleaching with 37% versus 10% carbamide peroxide: A randomized, blind clinical trial.

Sutil Elisama, da Silva Karine Letícia, Terra Renata Maria Oleniki et al. · J Esthet Restor Dent · 2022

PMID: 33169944RCT

Effect of bioactive glass paste on efficacy and post-operative sensitivity associated with at-home bleaching using 20% carbamide peroxide: a randomized controlled clinical trial.

Bizreh Yazan, Milly Hussam · Eur J Med Res · 2022

PMID: 36195927RCTFull text (PMC)

Evaluation of the color change and tooth sensitivity in treatments that associate violet LED with carbamide peroxide 10 %: A randomized clinical trial of a split-mouth design.

Gallinari Marjorie de Oliveira, Cintra Luciano Tavares Angelo, Barboza Ana Carolina Souza et al. · Photodiagnosis Photodyn Ther · 2020

PMID: 32014581RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Dentist

NUCC 122300000X

Oral and Maxillofacial Pathology Dentistry

Dentist — Oral and Maxillofacial Pathology

NUCC 1223P0106X

Find a Provider

Health Goals

Goals connected through associated conditions

Support Oral Health

Quick Facts

Type: Substance / Medication
Fully Specified Name: Carbamide peroxide (substance)
SNOMED CT: 90581007
UMLS CUI: C0108342
RxNorm CUI: 47686

Clinical Data

This intervention maps to 13 entities in the Healos knowledge graph.

6

Conditions

4

Biomarkers

2

Specialists

0

Symptoms

108

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.