Substance / Medication

Cefotetan

Overview

Active Ingredient
cefotetan
RxNorm CUI
2187

Indications

To reduce the development of drug-resistant bacteria and maintain the effectiveness of cefotetan and other antibacterial drugs, cefotetan should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria. When culture and susceptibility information are available, they should be considered in selecting or modifying antibacterial therapy. In the absence of such data, local epidemiology and susceptibility patterns may contribute to the emp

Labeler: Hikma Pharmaceuticals USA Inc.Updated: 2024-04-11T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Cefotetan is contraindicated in patients with a known allergy to the cephalosporin group of antibiotics and in those individuals who have experienced a cephalosporin associated hemolytic anemia.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

121 trials linked to this intervention

121
Total Trials
30
Recruiting
15
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Prevention of renal stone disease recurrence. A systematic review of contemporary pharmaceutical options.
Sfoungaristos Stavros, Gofrit Ofer N, Yutkin Vladimir et al. · Expert Opin Pharmacother · 2015
PMID: 25881654Meta-Analysis
Pharmacokinetic differences between the epimers of cefotetan disodium after single intravenous injection in healthy Chinese volunteers.
Su Meng-xiang, Liu Min-hong, Di Bin et al. · Eur J Drug Metab Pharmacokinet · 2011
PMID: 21915733RCT
Strategy to control catheter encrustation with citrated drinks: a randomized crossover study.
Khan Azhar, Housami Fadi, Melotti Roberto et al. · J Urol · 2010
PMID: 20171661RCT
Infection after elective colorectal surgery: bacteriological analysis of failures in a randomized trial of cefotetan vs. ertapenem prophylaxis.
Goldstein Ellie J C, Citron Diane M, Merriam C Vreni et al. · Surg Infect (Larchmt) · 2009
PMID: 19226203RCT
Pathogenesis of Proteus mirabilis in Catheter-Associated Urinary Tract Infections.
Yuan Fei, Huang Ziye, Yang Tongxin et al. · Urol Int · 2021
PMID: 33691318Review
Bacterial biofilm formation on indwelling urethral catheters.
Pelling H, Nzakizwanayo J, Milo S et al. · Lett Appl Microbiol · 2019
PMID: 30811615Review
Pathogenesis ofInfection.
Armbruster Chelsie E, Mobley Harry L T, Pearson Melanie M · EcoSal Plus · 2018
PMID: 29424333ReviewFull text (PMC)
From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis.
Norsworthy Allison N, Pearson Melanie M · Trends Microbiol · 2017
PMID: 28017513ReviewFull text (PMC)
Activity of Cefotetan against ESBL-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Isolates from the MERINO Trial.
Stewart Adam G, Cottrell Kyra, Henderson Andrew et al. · Microbiol Spectr · 2021
PMID: 34232101TrialFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Cefotetan (substance)
SNOMED CT
13585009
UMLS CUI
C0007555
RxNorm CUI
2187
Labeler
Hikma Pharmaceuticals USA Inc.

Clinical Data

This intervention maps to 19 entities in the Ltrl knowledge graph.

19
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
121
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.