Substance / Medication

Chlorothiazide

Overview

Active Ingredient
chlorothiazide
RxNorm CUI
2396

Indications

DIURIL is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. DIURIL has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomerulonephritis, and chronic renal failure. DIURIL is indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms o

Labeler: Salix Pharmaceuticals, IncUpdated: 2021-11-01T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

Anuria. Hypersensitivity to this product or to other sulfonamide-derived drugs.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

1 trials linked to this intervention

1
Total Trials
0
Recruiting
1
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Efficacy and Safety of Chlortalidone and Hydrochlorothiazide in Prevention of Cardiovascular Diseases.
Song Xiang-Ning, Wang Liang, Shen Zhu-Jun · Rev Cardiovasc Med · 2024
PMID: 39484134Meta-AnalysisFull text (PMC)
Hydrochlorothiazide use and risk of keratinocyte carcinoma and melanoma: A multisite population-based cohort study.
Azoulay Laurent, St-Jean Audray, Dahl Matthew et al. · J Am Acad Dermatol · 2023
PMID: 37105517Meta-Analysis
Hydrochlorothiazide use is associated with the risk of cutaneous and lip squamous cell carcinoma: A systematic review and meta-analysis.
de Macedo Andrade Ana Cláudia, Felix Fernanda Aragão, França Glória Maria et al. · Eur J Clin Pharmacol · 2022
PMID: 35258665Meta-Analysis
A Systematic Review and Meta-Analysis of Metolazone Compared to Chlorothiazide for Treatment of Acute Decompensated Heart Failure.
Steuber Taylor D, Janzen Kristin M, Howard Meredith L · Pharmacotherapy · 2020
PMID: 32639593Meta-Analysis
[Hydrochlorothiazide use and risk of skin cancers: A systematic review].
Becquart O, Guillot B, Bourrain J-L et al. · Rev Med Interne · 2019
PMID: 31101331Meta-Analysis
Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide-meta-analysis.
Dineva Stela, Uzunova Katya, Pavlova Velichka et al. · J Hum Hypertens · 2019
PMID: 31595024Meta-AnalysisFull text (PMC)
Genome-Wide and Gene-Based Meta-Analyses Identify Novel Loci Influencing Blood Pressure Response to Hydrochlorothiazide.
Salvi Erika, Wang Zhiying, Rizzi Federica et al. · Hypertension · 2017
PMID: 27802415Meta-AnalysisFull text (PMC)
Hydrochlorothiazide hypertension treatment induced metabolic effects in type 2 diabetes: a meta-analysis of parallel-design RCTs.
Lin J-J, Chang H-C, Ku C-T et al. · Eur Rev Med Pharmacol Sci · 2016
PMID: 27424996Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Chlorothiazide (substance)
SNOMED CT
372782002
UMLS CUI
C0008273
RxNorm CUI
2396
Labeler
Salix Pharmaceuticals, Inc

Clinical Data

This intervention maps to 13 entities in the Healos knowledge graph.

6
Conditions
4
Biomarkers
2
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.

Chlorothiazide — Conditions, Biomarkers & Specialists | Healos | Healos