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Substance / Medication

Ciclopirox

SNOMED 372854000UMLS C0055711

Overview

Active Ingredient
ciclopirox
RxNorm CUI
21090

Indications

Ciclopirox shampoo, 1 % is indicated for the topical treatment of seborrheic dermatitis of the scalp in adults.

Labeler: Encube Ethicals, Inc.Updated: 2026-01-30T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

None.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Tinea pedis
Candidiasis of skin
Pityriasis versicolor
Onychomycosis

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Diode Laser and Red-Laser Photodynamic Therapy Versus Ciclopirox 8% HPCH Nail Lacquer for the Treatment of Onychomycosis: A Randomised Controlled Trial.
García-Oreja Sara, Álvaro-Afonso Francisco Javier, Navarro-Pérez David et al. · Mycoses · 2025
PMID: 41024682RCTFull text (PMC)
Nail penetration and predicted mycological efficacy of an innovative hydrosoluble ciclopirox nail lacquer vs. a standard amorolfine lacquer in healthy subjects.
Monti D, Herranz U, Dal Bo L et al. · J Eur Acad Dermatol Venereol · 2013
PMID: 22449201RCT
Double-blind clinical trial for evaluating the effectiveness and tolerability of Ageratina pichinchensis extract on patients with mild to moderate onychomycosis. A comparative study with ciclopirox.
Romero-Cerecero Ofelia, Zamilpa Alejandro, Jiménez-Ferrer Jesús Enrique et al. · Planta Med · 2008
PMID: 18671197RCT
Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis.
Ratnavel Ravi C, Squire Ruth A, Boorman Graham C · J Dermatolog Treat · 2007
PMID: 17520465RCT
Treatment of head and neck dermatitis with ciclopiroxolamine cream--results of a double-blind, placebo-controlled study.
Mayser Peter, Kupfer Jörg, Nemetz Diana et al. · Skin Pharmacol Physiol · 2006
PMID: 16612143RCT
Retrospective study of onychomycosis patients treated with ciclopirox 8% HPCH and oral antifungals applying artificial intelligence to electronic health records.
Roustan Gastón, López Estébaranz José Luis, De La Cueva Pablo et al. · Sci Rep · 2025
PMID: 40744950ObservationalFull text (PMC)
Tacrolimus 0.1% versus ciclopiroxolamine 1% for maintenance therapy in patients with severe facial seborrheic dermatitis: A multicenter, double-blind, randomized controlled study.
Joly Pascal, Tejedor Ines, Tetart Florence et al. · J Am Acad Dermatol · 2021
PMID: 33010323Observational
Efficacy and tolerability of 1% ciclopirox shampoo in the treatment of moderate-to-severe scalp seborrheic dermatitis: a multicenter, prospective, assessor-blinded trial.
Veraldi Stefano, Barbareschi Mauro, Martella Alessandro et al. · G Ital Dermatol Venereol · 2019
PMID: 31001967Observational
MODELLING AND BIOPHARMACEUTICAL EVALUATION OF CICLOPIROX OLAMINE GELS.
Mazurkeviciute Agne, Ramanauskiene Kristina, Askiene Marija Iv et al. · Acta Pol Pharm · 2017
PMID: 29624259Observational
In vitro permeation and penetration of ciclopirox olamine from poloxamer 407-based formulations--comparison of isolated human stratum corneum, bovine hoof plates and keratin films.
Täuber Anja, Müller-Goymann Christel C · Int J Pharm · 2015
PMID: 25895717Observational

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Ciclopirox (substance)
SNOMED CT
372854000
UMLS CUI
C0055711
RxNorm CUI
21090
Labeler
Encube Ethicals, Inc.

Clinical Data

This intervention maps to 4 entities in the Healos knowledge graph.

4
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.