Substance / Medication

Citalopram

Overview

Active Ingredient
citalopram
RxNorm CUI
2556

Indications

Citalopram hydrobromide tablets are indicated for the treatment of depression. CLINICAL PHARMACOLOGY The efficacy of citalopram hydrobromide tablets in the treatment of depression was established in 4 to 6 week, controlled trials of outpatients whose diagnosis corresponded most closely to the DSM-III and DSM-III-R category of major depressive disorder (see). A major depressive episode (DSM-lV) implies a prominent and relatively persistent (nearly every day for at least 2 weeks) depressed or dysp

Labeler: State of Florida DOH Central PharmacyUpdated: 2010-08-04T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

WARNINGS: Clinical Worsening and Suicide Risk PRECAUTIONS: Information for Patients PRECAUTIONS: Pediatric Use Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents, and young adults in short-term studies of major depressive d

Contraindications

When this intervention should not be used

WARNINGS Concomitant use in patients taking monoamine oxidase inhibitors (MAOIs) is contraindicated (see). PRECAUTIONS Concomitant use in patients taking pimozide is contraindicated (see). Citalopram hydrobromide tablets are contraindicated in patients with a hypersensitivity to citalopram or any of

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

31 trials linked to this intervention

31
Total Trials
2
Recruiting
15
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Escitalopram and functional connectivity in major depressive disorder: A systematic review.
Turiaco Fabrizio, Arnone Federico, Drago Antonio et al. · J Psychopharmacol · 2025
PMID: 41025521Meta-Analysis
Effects of the selective serotonin reuptake inhibitors citalopram and escitalopram on glucolipid metabolism: a systematic review.
Dai Yajing, Zhao Mingzhe, Li Mian et al. · Front Endocrinol (Lausanne) · 2025
PMID: 40600014Meta-AnalysisFull text (PMC)
Comparing the effect of fluoxetine, escitalopram, and sertraline, on the level of BDNF and depression in preclinical and clinical studies: a systematic review.
Talaee Nastaran, Azadvar Shataw, Khodadadi Sanaz et al. · Eur J Clin Pharmacol · 2024
PMID: 38558317Meta-Analysis
Escitalopram versus other antidepressive agents for major depressive disorder: a systematic review and meta-analysis.
Yin Juntao, Song Xiaoyong, Wang Chaoyang et al. · BMC Psychiatry · 2023
PMID: 38001423Meta-AnalysisFull text (PMC)
Toward therapeutic drug monitoring of citalopram in depression? Insights from a systematic review.
Xu Na, Song Zaiwei, Jiang Dan et al. · Front Psychiatry · 2023
PMID: 37181880Meta-AnalysisFull text (PMC)
Prediction of Ventricular Arrhythmias by QRS/QTc - Ratio in Citalopram or Escitalopram Intoxication.
Dietrichs Erik Sveberg, Smith Godfrey L · Front Med (Lausanne) · 2022
PMID: 35372426Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Citalopram (substance)
SNOMED CT
372596005
UMLS CUI
C0008845
RxNorm CUI
2556
Labeler
State of Florida DOH Central Pharmacy

Clinical Data

This intervention maps to 14 entities in the Healos knowledge graph.

8
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
31
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.