Substance / Medication

Clostridium histolyticum collagenase

Overview

Active Ingredient
collagenase Clostridium histolyticum
RxNorm CUI
898492

Indications

◊ 2, 3, 4, 5, 6, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18 3, 4, 5, 7, 16, 19, 20, 21 Collagenase SantylOintment is indicated for debriding chronic dermal ulcersand severely burned areas.

Labeler: SMITH & NEPHEW, INCUpdated: 2019-05-17T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

◊ Collagenase SantylOintment is contraindicated in patients who have shown local or systemic hypersensitivity to collagenase.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Research Evidence

Published studies and systematic reviews

Sort:
Polylactic Acid Skin Substitute in Pediatric Burn Management: A Systematic Literature Review and Meta-Analysis.
Nguyen Antoinette T, Chikoti Rishika, Bell Derek · J Burn Care Res · 2026
PMID: 40684799Meta-Analysis
Impact of the COVID pandemic on melanoma thickness and ulceration: a meta-analysis.
Scharf Camila, Mongardini Federico M, Fisone Francesca et al. · Int J Dermatol · 2025
PMID: 39095953Meta-Analysis
Bromelain-Based Enzymatic Debridement Versus Standard of Care in Deep Burn Injuries: A Systematic Review and Meta-Analysis.
De Freitas Lucas R, Udoma-Udofa Ofonime Chantal, Reginato Pedro Henrique et al. · J Burn Care Res · 2025
PMID: 39259807Meta-Analysis
The prevalence of posttraumatic stress disorder symptomatology and diagnosis in burn survivors: a systematic review and meta-analysis.
Boersma-van Dam Elise, Shepherd Laura, van de Schoot Rens et al. · Health Psychol Rev · 2025
PMID: 39511919Meta-Analysis
Pinch Grafting: A Systematic Review of Modern Perspectives and Applications in Dermatologic Surgery and Wound Healing.
Jeha George M, Hill Emma, Taylor Laura et al. · Dermatol Surg · 2024
PMID: 38630594Meta-Analysis
Use of propolis for skin wound healing: systematic review and meta-analysis.
Machado Velho Julia Carnelós, França Thais Amaral, Malagutti-Ferreira Maria José et al. · Arch Dermatol Res · 2023
PMID: 36418601Meta-Analysis
Systemic pharmacological treatment of digital ulcers in systemic sclerosis: a systematic literature review.
Ross Laura, Maltez Nancy, Hughes Michael et al. · Rheumatology (Oxford) · 2023
PMID: 37335850Meta-AnalysisFull text (PMC)

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Clostridium histolyticum collagenase (substance)
SNOMED CT
56355009
UMLS CUI
C0009053
RxNorm CUI
898492
Labeler
SMITH & NEPHEW, INC

Clinical Data

This intervention maps to 5 entities in the Ltrl knowledge graph.

5
Conditions
0
Biomarkers
0
Specialists
0
Symptoms

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.