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Substance / Medication

Danaparoid

SNOMED 372564002UMLS C0259507

Overview

Active Ingredient
danaparoid
RxNorm CUI
78484

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Pulmonary embolism
Venous thrombosis
Thrombocytopenic disorder
Thromboembolic disorder

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Hemoglobin

LOINC 718-7

secondary

Leukocytes

LOINC 26464-8

secondary

Platelets

LOINC 777-3

primary

Clinical Trials

44 trials linked to this intervention

44
Total Trials
14
Recruiting
7
With Results

Recent Trials

Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin

NCT00039858Phase 4Completed24 enrolled

International Multi Centre Randomized Clinical Trial Of Anticoagulation In Children Following Fontan Procedures

NCT00182104Phase 4Completed111 enrolled

Trial of the Effect of Low-Molecular-Weight Heparin (LMWH) Versus Warfarin on Mortality in the Long-Term Treatment of Proximal Deep Vein Thrombosis (DVT) (Main LITE Study)

NCT00203580Phase 4Completed910 enrolled

Assessment of Long-Term Out-of-Hospital Treatment of Patients With Proximal Deep Vein Thrombosis (DVT) Using Low-Molecular-Weight Heparin (LMWH) Versus LMWH Followed by Warfarin

NCT00203658Phase 4Completed400 enrolled

Cystic Fibrosis and Totally Implantable Vascular Access Devices

NCT00244270Phase 4Completed97 enrolled
View all 44 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:
Treatment of 51 pregnancies with danaparoid because of heparin intolerance.
Lindhoff-Last Edelgard, Kreutzenbeck Hans-Joachim, Magnani Harry N · Thromb Haemost · 2005
PMID: 15630492Meta-Analysis
Optimizing risk stratification in portal vein thrombosis after splenectomy and its primary prophylaxis with antithrombin III concentrates and danaparoid sodium in liver cirrhosis with portal hypertension.
Kawanaka Hirofumi, Akahoshi Tomohiko, Itoh Shinji et al. · J Am Coll Surg · 2014
PMID: 25256370Trial
[Danaparoid in pregnancy in cases of heparin intolerance - use in 59 cases].
Schindewolf M, Magnani H N, Lindhoff-Last E · Hamostaseologie · 2007
PMID: 17479171Trial
The effects of unfractionated heparin, low molecular weight heparin and danaparoid on the thromboelastogram (TEG): an in-vitro comparison of standard and heparinase-modified TEGs with conventional coagulation assays.
Coppell Jason A, Thalheimer Ulrich, Zambruni Andrea et al. · Blood Coagul Fibrinolysis · 2006
PMID: 16479191Trial
On the prophylactic and therapeutic use of danaparoid sodium (Orgaran) in patients with heparin-induced thrombocytopenia.
Schenk Joachim F, Pindur Gerhard, Stephan Bernhard et al. · Clin Appl Thromb Hemost · 2003
PMID: 12643320Trial
Heparin versus danaparoid in off-pump coronary bypass grafting: results of a prospective randomized clinical trial.
Carrier Michel, Robitaille Danielle, Perrault Louis P et al. · J Thorac Cardiovasc Surg · 2003
PMID: 12579101Trial
Pharmacokinetic studies of dalteparin (Fragmin), enoxaparin (Clexane), and danaparoid sodium (Orgaran) in stable chronic hemodialysis patients.
Polkinghorne Kevan R, McMahon Lawrence P, Becker Gavin J · Am J Kidney Dis · 2002
PMID: 12407644Trial
A comparison of danaparoid and lepirudin in heparin-induced thrombocytopenia.
Farner B, Eichler P, Kroll H et al. · Thromb Haemost · 2001
PMID: 11434701Trial
Prospective randomised open-label comparison of danaparoid with dextran 70 in the treatment of heparin-induced thrombocytopaenia with thrombosis: a clinical outcome study.
Chong B H, Gallus A S, Cade J F et al. · Thromb Haemost · 2001
PMID: 11816702Trial
[Danaparoid (Orgaran) as an antiocoagulant for mechanical autotransfusion with Cell Saver 5 (Hemonetics)].
von Lüpke U, Marx A, Tessmann R et al. · Anaesthesist · 2001
PMID: 11220255Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X
Hematology (Internal Medicine) Physician

Internal Medicine — Hematology

NUCC 207RH0000X
Find a Provider

Health Goals

Goals connected through associated conditions

Optimize Iron and Blood Health

Quick Facts

Type
Substance / Medication
Fully Specified Name
Danaparoid (substance)
SNOMED CT
372564002
UMLS CUI
C0259507
RxNorm CUI
78484

Clinical Data

This intervention maps to 10 entities in the Ltrl knowledge graph.

4
Conditions
3
Biomarkers
2
Specialists
0
Symptoms
44
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.