Substance / Medication

Desipramine

SNOMED 372705002 UMLS C0011685

Overview

Active Ingredient

desipramine

RxNorm CUI

3247

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Depressive disorder

Attention deficit hyperactivity disorder

Affective psychosis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Calcidiol+ercalcidiol

LOINC 14635-7

secondary

Cobalamins

LOINC 2132-9

secondary

Thyrotropin

LOINC 3016-3

secondary

Clinical Trials

48 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Continuation Electroconvulsive Therapy Vs Medication to Prevent Relapses in Patients With Major Depressive Disorder

NCT00000375Phase 4Completed

Antidepressant Treatment of Melancholia in Late Life

NCT00000378Phase 4Completed110 enrolled

Optimizing Electroconvulsive Therapy for Depression

NCT00045916Phase 4Completed340 enrolled

Ethnic Variations in Antidepressant Response

NCT00047671Phase 4Completed400 enrolled

Research Evaluating the Value of Augmenting Medication With Psychotherapy

NCT00057551Phase 4Completed491 enrolled

View all 48 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

Desipramine for neuropathic pain in adults.

Hearn Leslie, Moore R Andrew, Derry Sheena et al. · Cochrane Database Syst Rev · 2014

PMID: 25246131Meta-AnalysisFull text (PMC)

A systematic review of the efficacy and safety of desipramine for treating ADHD.

Ghanizadeh Ahmad · Curr Drug Saf · 2013

PMID: 23914752Meta-Analysis

A randomized placebo-controlled trial of desipramine, cognitive behavioral therapy, and active placebo therapy for low back pain.

Gould Hilary M, Atkinson Joseph Hampton, Chircop-Rollick Tatiana et al. · Pain · 2020

PMID: 32068667RCT

Desipramine improves upper airway collapsibility and reduces OSA severity in patients with minimal muscle compensation.

Taranto-Montemurro Luigi, Sands Scott A, Edwards Bradley A et al. · Eur Respir J · 2016

PMID: 27799387RCTFull text (PMC)

Desipramine Increases Genioglossus Activity and Reduces Upper Airway Collapsibility during Non-REM Sleep in Healthy Subjects.

Taranto-Montemurro Luigi, Edwards Bradley A, Sands Scott A et al. · Am J Respir Crit Care Med · 2016

PMID: 26967681RCTFull text (PMC)

Evaluation of the likelihood of a selective CHK1 inhibitor (LY2603618) to inhibit CYP2D6 with desipramine as a probe substrate in cancer patients.

Hynes Scott M, Wickremsinhe Enaksha, Zhang Wei et al. · Biopharm Drug Dispos · 2015

PMID: 25296725RCT

Pharmacokinetic and pharmacodynamic interactions between almorexant, a dual orexin receptor antagonist, and desipramine.

Cruz Hans G, Hay Justin L, Hoever Petra et al. · Eur Neuropsychopharmacol · 2014

PMID: 24880753RCT

Citalopram versus desipramine in treatment resistant depression: effect of continuation or switching strategies: a randomized open study.

Souery Daniel, Serretti Alessandro, Calati Raffaella et al. · World J Biol Psychiatry · 2011

PMID: 21718212RCT

Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial.

Foster David C, Kotok Merrill Beth, Huang Li-Shan et al. · Obstet Gynecol · 2010

PMID: 20733439RCTFull text (PMC)

The effects of desvenlafaxine and paroxetine on the pharmacokinetics of the cytochrome P450 2D6 substrate desipramine in healthy adults.

Nichols Alice I, Fatato Penny, Shenouda Magdy et al. · J Clin Pharmacol · 2009

PMID: 19001559RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Internal Medicine Physician

Internal Medicine

NUCC 207R00000X

Psychiatry Physician

Psychiatry & Neurology — Psychiatry

NUCC 2084P0800X

Find a Provider

Health Goals

Goals connected through associated conditions

Support Mental Wellness

Quick Facts

Type: Substance / Medication
Fully Specified Name: Desipramine (substance)
SNOMED CT: 372705002
UMLS CUI: C0011685
RxNorm CUI: 3247

Clinical Data

This intervention maps to 9 entities in the Healos knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.