Substance / Medication

Dexrazoxane

Overview

Active Ingredient
dexrazoxane
RxNorm CUI
42736

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

3 trials linked to this intervention

3
Total Trials
3
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Dexrazoxane for preventing or reducing cardiotoxicity in adults and children with cancer receiving anthracyclines.
de Baat Esmée C, Mulder Renée L, Armenian Saro et al. · Cochrane Database Syst Rev · 2022
PMID: 36162822Meta-AnalysisFull text (PMC)
Dexrazoxane Significantly Reduces Anthracycline-induced Cardiotoxicity in Pediatric Solid Tumor Patients: A Systematic Review.
Liesse Kelly, Harris Jamie, Chan Megan et al. · J Pediatr Hematol Oncol · 2018
PMID: 29432315Meta-AnalysisFull text (PMC)
Dexrazoxane : a review of its use for cardioprotection during anthracycline chemotherapy.
Cvetković Risto S, Scott Lesley J · Drugs · 2005
PMID: 15892593Meta-Analysis
Late health outcomes after dexrazoxane treatment: A report from the Children's Oncology Group.
Chow Eric J, Aplenc Richard, Vrooman Lynda M et al. · Cancer · 2022
PMID: 34644414RCTFull text (PMC)
Dexrazoxane protects breast cancer patients with diabetes from chemotherapy-induced cardiotoxicity.
Sun Fangyi, Qi Xiaoyong, Geng Cuizhi et al. · Am J Med Sci · 2015
PMID: 25723884RCT
Late Mortality After Dexrazoxane Treatment: A Report From the Children's Oncology Group.
Chow Eric J, Asselin Barbara L, Schwartz Cindy L et al. · J Clin Oncol · 2015
PMID: 26014292RCTFull text (PMC)
[Protective effect of dexrazoxane on cardiotoxicity in breast cancer patients who received anthracycline-containing chemotherapy].
Wang Pei, Zhang Sheng, Zhang Xiao-bei et al. · Zhonghua Zhong Liu Za Zhi · 2013
PMID: 23714670RCT

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Dexrazoxane (substance)
SNOMED CT
108825009
UMLS CUI
C0086444
RxNorm CUI
42736

Clinical Data

This intervention maps to 1 entities in the Healos knowledge graph.

1
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
3
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.