Substance / Medication

Diazepam

Overview

Active Ingredient
diazepam
RxNorm CUI
3322

Indications

Diazepam tablets are indicated for the management of anxiety disorders or for the short-term relief of the symptoms of anxiety. Anxiety or tension associated with the stress of everyday life usually does not require treatment with an anxiolytic. In acute alcohol withdrawal, diazepam tablets may be useful in the symptomatic relief of acute agitation, tremor, impending or acute delirium tremens and hallucinosis. Diazepam tablets are a useful adjunct for the relief of skeletal muscle spasm due to r

Labeler: Safecor Health, LLCUpdated: 2026-02-20T00:00:00.000ZFull label on DailyMed

Boxed Warning

FDA Black Box Warning

WARNINGS PRECAUTIONS Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing of these drugs in patients for whom alternative treatment options are inadequate. Limit dosages and durations to the minimum r

Contraindications

When this intervention should not be used

Diazepam tablets are contraindicated in patients with a known hypersensitivity to diazepam and, because of lack of sufficient clinical experience, in pediatric patients under 6 months of age. Diazepam tablets are also contraindicated in patients with myasthenia gravis, severe respiratory insufficien

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

1 trials linked to this intervention

1
Total Trials
0
Recruiting
0
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Diazepam promotes active avoidance extinction associating with increased dorsal CA3 and amygdala activity.
Zhang Juan, Li Wenjun, Liao Taohong et al. · Brain Res · 2023
PMID: 37429455Meta-Analysis
Application of a diazepam milligram equivalency algorithm to assess benzodiazepine dose intensity in Rhode Island in 2018.
Borrelli Eric P, Bratberg Jeffrey, Hallowell Benjamin D et al. · J Manag Care Spec Pharm · 2022
PMID: 34949119Meta-AnalysisFull text (PMC)
A Systematic Review of Intravaginal Diazepam for the Treatment of Pelvic Floor Hypertonic Disorder.
Stone Rebecca H, Abousaud Marin, Abousaud Aseala et al. · J Clin Pharmacol · 2020
PMID: 33274514Meta-Analysis
Lorazepam or diazepam for convulsive status epilepticus: A meta-analysis.
Wu Wei, Zhang Liqun, Xue Rong · J Clin Neurosci · 2016
PMID: 27052258Meta-Analysis
Magnesium sulphate versus diazepam for eclampsia.
Duley Lelia, Henderson-Smart David J, Walker Godfrey Ja et al. · Cochrane Database Syst Rev · 2010
PMID: 21154341Meta-AnalysisFull text (PMC)
Diazepam for treating tetanus.
Okoromah C N, Lesi F E A · Cochrane Database Syst Rev · 2004
PMID: 14974046Meta-AnalysisFull text (PMC)
Intermittent diazepam and continuous phenobarbital to treat recurrence of febrile seizures: a systematic review with meta-analysis.
Masuko Alice Hatsue, Castro Aldemar Araujo, Santos Gustavo Rocha et al. · Arq Neuropsiquiatr · 2003
PMID: 14762586Meta-Analysis
Magnesium sulphate versus diazepam for eclampsia.
Duley L, Henderson-Smart D · Cochrane Database Syst Rev · 2003
PMID: 14583910Meta-Analysis
Efficacy of diazepam as an anti-anxiety agent: meta-analysis of double-blind, randomized controlled trials carried out in Japan.
Inada Toshiya, Nozaki Shoko, Inagaki Ataru et al. · Hum Psychopharmacol · 2003
PMID: 12923829Meta-Analysis

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type
Substance / Medication
Fully Specified Name
Diazepam (substance)
SNOMED CT
387264003
UMLS CUI
C0012010
RxNorm CUI
3322
Labeler
Safecor Health, LLC

Clinical Data

This intervention maps to 2 entities in the Healos knowledge graph.

2
Conditions
0
Biomarkers
0
Specialists
0
Symptoms
1
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Healos clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.