Substance / Medication

Dichlorphenamide

Overview

Active Ingredient
dichlorphenamide
RxNorm CUI
3353

Indications

KEVEYIS is indicated for the treatment of primary hyperkalemic periodic paralysis, primary hypokalemic periodic paralysis, and related variants.

Labeler: Xeris Pharmaceuticals, Inc.Updated: 2025-12-23T00:00:00.000ZFull label on DailyMed

Contraindications

When this intervention should not be used

KEVEYIS is contraindicated in the following circumstances: Warnings and Precautions (5.1) [see] Hypersensitivity to dichlorphenamide or other sulfonamides Warnings and Precautions (5.2) Drug Interactions (7.1) [seeand] Concomitant use of KEVEYIS and high dose aspirin Warnings and Precautions (5.4) [

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Administration & Protocol

Dosing, route, and treatment protocol

Detailed dosage and administration information is available in the full FDA drug label.

View full prescribing information on DailyMed

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

Clinical Trials

136 trials linked to this intervention

136
Total Trials
11
Recruiting
53
With Results

Research Evidence

Published studies and systematic reviews

Sort:
Safety and efficacy of dichlorphenamide in patients with periodic paralysis: A systematic review and meta-analysis.
Haider Samna, Siddiqui Ahmed Daud, Asad Muhammad et al. · Neuromuscul Disord · 2026
PMID: 41371188Meta-Analysis
Visual Acuity Outcomes After Trans-scleral Cyclophotocoagulation: A Systematic Review and Meta-analysis.
Zajner Chris, Pandya Bhadra, Balas Michael et al. · Am J Ophthalmol · 2026
PMID: 40915521Meta-Analysis
PreserFlo MicroShunt versus trabeculectomy: an updated meta-analysis and systematic review.
Governatori Lorenzo, Oliverio Leandro, Mermoud André et al. · Graefes Arch Clin Exp Ophthalmol · 2025
PMID: 39394492Meta-Analysis
GLP-1 Receptor Agonists Use and Incidence of Glaucoma: A Systematic Review and Meta-Analysis.
Amaral Dillan Cunha, Guedes Jaime, Cruz Matheus Ribeiro Barbosa et al. · Am J Ophthalmol · 2025
PMID: 39732312Meta-Analysis
Machine Learning Approaches in High Myopia: Systematic Review and Meta-Analysis.
Zuo Huiyi, Huang Baoyu, He Jian et al. · J Med Internet Res · 2025
PMID: 39753217Meta-AnalysisFull text (PMC)
Association between gene polymorphisms and glaucoma susceptibility among Africans: a systematic review and meta-analysis.
Asiamah Randy, Kyei Samuel, Owusu Paul et al. · Ophthalmic Genet · 2025
PMID: 39757584Meta-Analysis
Impact of Glaucoma Surgery on Corneal Graft Survival After Keratoplasty: A Systematic Review and Meta-Analysis.
Tawfik Abdelrahman M, Kasem Rawan A, Wesh Zeyad M et al. · J Glaucoma · 2025
PMID: 39841092Meta-Analysis
Long-term efficacy and safety of dichlorphenamide for treatment of primary periodic paralysis.
Sansone Valeria A, Johnson Nicholas E, Hanna Michael G et al. · Muscle Nerve · 2021
PMID: 34129236RCTFull text (PMC)
Randomized trials of dichlorphenamide in the periodic paralyses. Working Group on Periodic Paralysis.
Tawil R, McDermott M P, Brown R et al. · Ann Neurol · 2000
PMID: 10632100Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Adverse reaction and safety data for this drug is sourced from the FDA-approved label.

View adverse reactions & drug interactions on DailyMed

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Specialists

Providers who commonly manage this intervention

Health Goals

Goals connected through associated conditions

Quick Facts

Type
Substance / Medication
Fully Specified Name
Diclofenamide (substance)
SNOMED CT
387111009
UMLS CUI
C0012086
RxNorm CUI
3353
Labeler
Xeris Pharmaceuticals, Inc.

Clinical Data

This intervention maps to 4 entities in the Ltrl knowledge graph.

1
Conditions
1
Biomarkers
1
Specialists
0
Symptoms
136
Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.