Substance / Medication

Disodium pamidronate

SNOMED 396032007 UMLS C0356588

Overview

Clinical overview including description, indications, and evidence base is pending physician authorship or FDA SPL integration. Graph-derived relationship data is available below.

Indications & Related Conditions

Conditions associated via SNOMED clinical relationships

Menopausal osteoporosis

Hypercalcemia

Postmenopausal osteoporosis

Osteolysis

Administration & Protocol

Dosing, route, and treatment protocol

Administration details including route, dosing schedules, preparation instructions, and contraindications are pending physician authorship.

Monitoring & Follow-Up

Biomarkers relevant to this intervention via related conditions

No monitoring biomarkers have been mapped yet. Biomarker-intervention linkages are derived through related conditions and will expand as the knowledge graph grows.

Clinical Trials

8 trials linked to this intervention

Total Trials

Recruiting

With Results

Recent Trials

Initial Dosing of Paricalcitol in Secondary Hyperparathyroidism

NCT00307840Phase 4Completed

Does Treatment of Hypovitaminosis D Increase Calcium Absorption?

NCT00581828Phase 4Completed19 enrolled

Paricalcitol Versus Calcitriol for Efficacy and Safety in Stage 3/4 Chronic Kidney Disease (CKD) With Secondary Hyperparathyroidism (SHPT)

NCT00823303Phase 4Completed110 enrolled

Effectiveness and Safety of IV Zemplar in Patients on Hemodialysis and With Secondary Hyperparathyroidism Using iPTH/100 as Initial Dose

NCT00891813Phase 4Completed100 enrolled

Parathyroidectomy vs Cinacalcet in the Treatment of Secondary Hyperparathyroidism Post Renal Transplantation

NCT01178450Phase 4Completed30 enrolled

View all 8 trials on ClinicalTrials.gov

Research Evidence

Published studies and systematic reviews

Sort:

1,25-dihydroxyvitamin D-mediated hypercalcemia associated with solid organ malignancy: a systematic review.

Charoenngam Nipith, Ponvilawan Ben, Rujirachun Pongprueth et al. · Minerva Endocrinol (Torino) · 2025

PMID: 34581546Meta-Analysis

Polyethylene liner cementation into a well-fixed metal acetabular shell for the management of periacetabular osteolysis: a systematic review.

Malahias Michael-Alexander, Ma Qian-Li, Jang Seong J et al. · Eur J Orthop Surg Traumatol · 2022

PMID: 34605989Meta-Analysis

The lexicon for periprosthetic bone loss versus osteolysis after cervical disc arthroplasty: a systematic review.

Wahbeh Jenna M, Park Sang-Hyun, Campbell Patricia et al. · Eur Spine J · 2022

PMID: 34999945Meta-Analysis

Are additional screws required for press-fit fixation of cementless acetabular cups? A systematic review and meta-analysis.

Ni Shenghui, Luo Peng, Guo Lei et al. · J Orthop Traumatol · 2022

PMID: 35142933Meta-AnalysisFull text (PMC)

Comparable results between crosslinked polyethylene and conventional ultra-high molecular weight polyethylene implanted in total knee arthroplasty: systematic review and meta-analysis of randomised clinical trials.

Bistolfi Alessandro, Giustra Fortunato, Bosco Francesco et al. · Knee Surg Sports Traumatol Arthrosc · 2022

PMID: 35182171Meta-AnalysisFull text (PMC)

An intra-patient dose-escalation study of disodium pamidronate plus radiotherapy versus radiotherapy alone for the treatment of osteolytic metastases. Monitoring of recalcification using image-processing techniques.

Kouloulias E Vassilis, Kouvaris R John, Antypas Christos et al. · Strahlenther Onkol · 2003

PMID: 12835884Trial

Radiotherapy in conjunction with intravenous infusion of 180 mg of disodium pamidronate in management of osteolytic metastases from breast cancer: clinical evaluation, biochemical markers, quality of life, and monitoring of recalcification using assessments of gray-level histogram in plain radiographs.

Kouloulias Vassilis, Matsopoulos George, Kouvaris John et al. · Int J Radiat Oncol Biol Phys · 2003

PMID: 12909227Trial

Use of image processing techniques to assess effect of disodium pamidronate in conjunction with radiotherapy in patients with bone metastases.

Kouloulias Vassilios E, Dardoufas Costas E, Kouvaris John R et al. · Acta Oncol · 2002

PMID: 12102162Trial

The role of disodium pamidronate in the management of bone pain due to malignancy.

Groff L, Zecca E, De Conno F et al. · Palliat Med · 2001

PMID: 12054147Trial

Intermittent oral disodium pamidronate in established osteoporosis: a 2 year double-masked placebo-controlled study of efficacy and safety.

Ryan P J, Blake G M, Davie M et al. · Osteoporos Int · 2000

PMID: 10793877Trial

Research data from MEDLINE/PubMed

Benefits & Expected Outcomes

Benefits, expected outcomes, efficacy data, and NNT (Number Needed to Treat) are pending physician authorship and evidence review.

Risks & Side Effects

Risk profile, common and serious adverse effects, contraindications, and drug interactions are pending physician authorship.

Related Symptoms

Symptoms associated with conditions this intervention addresses

No related symptoms have been mapped yet. Symptom linkages are derived through associated conditions.

Alternatives & Comparisons

Alternative treatments, comparison data, and clinical decision support are pending physician authorship.

Medical Disclaimer

This information is for educational purposes only and does not constitute medical advice, diagnosis, or treatment. Always consult with a qualified healthcare provider regarding any medical condition or treatment plan.

Do not start, stop, or change any treatment without consulting your healthcare provider.

Quick Facts

Type: Substance / Medication
Fully Specified Name: Disodium pamidronate (substance)
SNOMED CT: 396032007
UMLS CUI: C0356588

Clinical Data

This intervention maps to 4 entities in the Ltrl knowledge graph.

Conditions

Biomarkers

Specialists

Symptoms

Clinical Trials

Data is sourced from SNOMED CT, UMLS, and the Ltrl clinical knowledge graph. Content sections marked as pending require physician authorship. Consult a healthcare provider before starting any treatment.